DNA fragmentation induced by Fe ions in human cells: Shielding influence on spatially correlated damage

F. Antonelli, M. Belli, A. Campa, A. Chatterjee, V. Dini, G. Esposito, B. Rydberg, G. Simone, M. A. Tabocchini

Research output: Contribution to journalArticle

Abstract

Outside the magnetic field of the Earth, high energy heavy ions constitute a relevant part of the biologically significant dose to astronauts during the very long travels through space. The typical pattern of energy deposition in the matter by heavy ions on the microscopic scale is believed to produce spatially correlated damage in the DNA which is critical for radiobiological effects. We have investigated the influence of a lucite shielding on the initial production of very small DNA fragments in human fibroblasts irradiated with 1 GeV/u iron (Fe) ions. We also used γ-rays as reference radiation. Our results show: (1) a lower effect per incident ion when the shielding is used; (2) an higher DNA Double Strand Breaks (DSB) induction by Fe ions than by γ-rays in the size range 1-23 kbp; (3) a non-random DNA DSB induction by Fe ions.

Original languageEnglish
Pages (from-to)1353-1357
Number of pages5
JournalAdvances in Space Research
Volume34
Issue number6
DOIs
Publication statusPublished - Jan 1 2004

Keywords

  • DNA fragmentation
  • Fe ions in human cells
  • Radiation dose
  • Radiation risk
  • Radiation shielding

ASJC Scopus subject areas

  • Aerospace Engineering
  • Astronomy and Astrophysics
  • Geophysics
  • Atmospheric Science
  • Space and Planetary Science
  • Earth and Planetary Sciences(all)

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