DNA-functionalized nanopores for single molecule analysis

Valentina Mussi, Paola Fanzio, Luca Repetto, Giuseppe Firpo, Ugo Valbusa, Sara Stigliani, Paola Scaruffi, Gianpaolo Tonini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of biological "nanopores" as sensors for single molecules like DNA was recently demonstrated: the passage of the molecules through the pore separating two electrolyte-filled reservoirs is induced by a voltage application and detected as a current drop. Present attention is devoted to solid state nanopores, with obvious advantages, such as high stability, control of diameter, adjustable surface properties and the potential for integration into complex devices. We present results on DNA-functionalized solid state nanopore devices produced by using a Focused Ion Beam, to obtain an high throughput platform for gene expression profiling, that is for the rapid molecular diagnosis of tumours and other genetic diseases.

Original languageEnglish
Title of host publication2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009
Pages682-684
Number of pages3
Publication statusPublished - 2009
Event2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009 - Genoa, Italy
Duration: Jul 26 2009Jul 30 2009

Other

Other2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009
CountryItaly
CityGenoa
Period7/26/097/30/09

    Fingerprint

Keywords

  • Biosensors
  • DNA
  • Hybridization
  • Nanopores

ASJC Scopus subject areas

  • Process Chemistry and Technology
  • Electrical and Electronic Engineering

Cite this

Mussi, V., Fanzio, P., Repetto, L., Firpo, G., Valbusa, U., Stigliani, S., Scaruffi, P., & Tonini, G. (2009). DNA-functionalized nanopores for single molecule analysis. In 2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009 (pp. 682-684). [5394848]