Abstract
We report the results of a biological and molecular study carried out on 11 Italian families, with a total of 111 individuals in which adult dominant polycystic kidney disease segregates. A restriction fragment length polymorphism analysis was performed. Two families have shown a genetic heterogeneity even if not phenotypically different from the other ones: they resulted unlinked to 16p markers. A prenatal diagnosis has been performed in a family of the linked type.
Original language | English |
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Pages (from-to) | 57-59 |
Number of pages | 3 |
Journal | European Urology |
Volume | 21 |
Issue number | SUPPL. 1 |
Publication status | Published - 1992 |
Keywords
- Autosomal-dominant polycystic kidney disease
- DNA
- Genetic heterogeneity
- Presymptomatic diagnosis
ASJC Scopus subject areas
- Urology