DNA markers in diagnosis of adult dominant polycystic kidney disease

L. Venezianoa, A. R. D'Angelo, L. Burrai, G. Perugia, V. Gentile, L. Potenza, M. P. Iampieri, A. Novelletto, G. Novelli, M. Frontali

Research output: Contribution to journalArticle

Abstract

We report the results of a biological and molecular study carried out on 11 Italian families, with a total of 111 individuals in which adult dominant polycystic kidney disease segregates. A restriction fragment length polymorphism analysis was performed. Two families have shown a genetic heterogeneity even if not phenotypically different from the other ones: they resulted unlinked to 16p markers. A prenatal diagnosis has been performed in a family of the linked type.

Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalEuropean Urology
Volume21
Issue numberSUPPL. 1
Publication statusPublished - 1992

Keywords

  • Autosomal-dominant polycystic kidney disease
  • DNA
  • Genetic heterogeneity
  • Presymptomatic diagnosis

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Venezianoa, L., D'Angelo, A. R., Burrai, L., Perugia, G., Gentile, V., Potenza, L., Iampieri, M. P., Novelletto, A., Novelli, G., & Frontali, M. (1992). DNA markers in diagnosis of adult dominant polycystic kidney disease. European Urology, 21(SUPPL. 1), 57-59.