DNA methylation profiles of selected pro-inflammatory cytokines in Alzheimer disease

Vincenzina Nicolia, Rosaria A. Cavallaro, Irene Lopez-Gonzalez, Mauro Maccarrone, Sigfrido Scarpa, Isidre Ferrer, Andrea Fuso

Research output: Contribution to journalArticlepeer-review

Abstract

By means of functional genomics analysis, we recently described the mRNA expression profiles of various genes involved in the neuroinflammatory response in the brains of subjects with late-onset Alzheimer Disease (LOAD). Some of these genes, namely interleukin (IL)-1b and IL-6, showed distinct expression profiles with peak expression during the first stages of the disease and control-like levels at later stages. IL-1b and IL-6 genes are modulated by DNA methylation in different chronic and degenerative diseases; it is also well known that LOAD may have an epigenetic basis. Indeed, we and others have previously reported gene-specific DNA methylation alterations in LOAD and in related animal models. Based on these data, we studied the DNA methylation profiles, at single cytosine resolution, of IL-1b and IL-6 5'-flanking region by bisulphite modification in the cortex of healthy controls and LOAD patients at 2 different disease stages: Braak I-II/A and Braak V-VI/C. Our analysis provides evidence that neuroinflammation in LOAD is associated with (and possibly mediated by) epigenetic modifications.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalJournal of Neuropathology and Experimental Neurology
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Alzheimer disease
  • Cytokines
  • DNA methylation
  • Epigenetics
  • Neuroinflammation
  • Non-CpG methylation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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