Studio della metilazione del DNA nella valutazione della cancerogenicità di agenti ambientali e occupazionali

Translated title of the contribution: DNA methylotion analysis in environmental and occupational cancer research

A. Baccarelli, B. Marinelli, V. Bollati, B. Albetti, D. Consonni, M. Bonzini, A. C. Pesatori, Pier Alberto Bertazzi

Research output: Contribution to journalArticle

Abstract

The present paper reviews recent laboratory methods and experimental evidence concerning epigenetic biomarkers involved in carcinogenesis mechanisms. We introduce DNA methylation and its role in gene expression control. DNA methylation analysis may allow to identify early changes leading to cancer and other chronic diseases. We describe here strategies for laboratory analyses and their possible applications. We examine results from recent experimental studies suggesting that the effects of certain occupational agents are mediated by alterations in DNA methylation. Planning and conducting investigations on exposed human subjects will allow to verify whether DNA methylation changes identified in animal and in-vitro studies may be used as early-effect and susceptibility biomarkers. DNA methylation analysis has the potential for future applications in risk assessment and prevention programs conducted on subjects exposed to human carcinogens.

Original languageItalian
Pages (from-to)267-271
Number of pages5
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume27
Issue number3
Publication statusPublished - Jul 2005

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

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