DNA nanotechnology for cancer therapy

Vinit Kumar, Stefano Palazzolo, Samer Bayda, Giuseppe Corona, Giuseppe Toffoli, Flavio Rizzolio

Research output: Contribution to journalArticlepeer-review

Abstract

DNA nanotechnology is an emerging and exciting field, and represents a forefront frontier for the biomedical field. The specificity of the interactions between complementary base pairs makes DNA an incredible building material for programmable and very versatile two- and three-dimensional nanostructures called DNA origami. Here, we analyze the DNA origami and DNA-based nanostructures as a drug delivery system. Besides their physical-chemical nature, we dissect the critical factors such as stability, loading capability, release and immunocompatibility, which mainly limit in vivo applications. Special attention was dedicated to highlighting the boundaries to be overcome to bring DNA nanostructures closer to the bedside of patients.

Original languageEnglish
Pages (from-to)710-725
Number of pages16
JournalTheranostics
Volume6
Issue number5
DOIs
Publication statusPublished - Mar 20 2016

Keywords

  • Cancer
  • DNA
  • Doxorubicin
  • Drug delivery
  • Nanomedicine
  • Nanotechnology
  • Origami
  • Self-assembly

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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