DNA repair after UV and gamma irradiation. I. Rat spleen cells.

P. Rocchi, P. Perocco, S. Grilli, G. Arfellini, C. Franceschi, A. M. Ferreri, G. Prodi

Research output: Contribution to journalArticlepeer-review

Abstract

An in vitro microculture was set up to standardize DNA enzymatic repair in rat spleen lymphocytes after exposure to ultraviolet or gamma rays by measuring the tritiated thymidine uptake. A relation between irradiation dose and DNA repair is always observable when cell viability and scheduled DNA synthesis are taken into account. This micromethod utilizing rat spleen cells appears to be a suitable system for such a study since it permits a satisfactory evaluation of DNA repair.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalArchivio di scienze biologiche
Volume60
Issue number1-4
Publication statusPublished - Jan 1976

ASJC Scopus subject areas

  • Medicine(all)

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