DNA repair after UV and gamma irradiation. I. Rat spleen cells.

P. Rocchi, P. Perocco, S. Grilli, G. Arfellini, C. Franceschi, A. M. Ferreri, G. Prodi

Research output: Contribution to journalArticlepeer-review


An in vitro microculture was set up to standardize DNA enzymatic repair in rat spleen lymphocytes after exposure to ultraviolet or gamma rays by measuring the tritiated thymidine uptake. A relation between irradiation dose and DNA repair is always observable when cell viability and scheduled DNA synthesis are taken into account. This micromethod utilizing rat spleen cells appears to be a suitable system for such a study since it permits a satisfactory evaluation of DNA repair.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalArchivio di scienze biologiche
Issue number1-4
Publication statusPublished - Jan 1976

ASJC Scopus subject areas

  • Medicine(all)


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