TY - JOUR
T1 - DNA repair and aging
T2 - The impact of the p53 family
AU - Nicolai, Sara
AU - Rossi, Antonello
AU - Di Daniele, Nicola
AU - Melino, Gerry
AU - Annicchiarico-Petruzzelli, Margherita
AU - Raschellà, Giuseppe
PY - 2015
Y1 - 2015
N2 - Cells are constantly exposed to endogenous and exogenous factors that threaten the integrity of their DNA. The maintenance of genome stability is of paramount importance in the prevention of both cancer and aging processes. To deal with DNA damage, cells put into operation a sophisticated and coordinated mechanism, collectively known as DNA damage response (DDR). The DDR orchestrates different cellular processes, such as DNA repair, senescence and apoptosis. Among the key factors of the DDR, the related proteins p53, p63 and p73, all belonging to the same family of transcription factors, play multiple relevant roles. Indeed, the members of this family are directly involved in the induction of cell cycle arrest that is necessary to allow the cells to repair. Alternatively, they can promote cell death in case of prolonged or irreparable DNA damage. They also take part in a more direct task by modulating the expression of core factors involved in the process of DNA repair or by directly interacting with them. In this review we will analyze the fundamental roles of the p53 family in the aging process through their multifaceted function in DDR.
AB - Cells are constantly exposed to endogenous and exogenous factors that threaten the integrity of their DNA. The maintenance of genome stability is of paramount importance in the prevention of both cancer and aging processes. To deal with DNA damage, cells put into operation a sophisticated and coordinated mechanism, collectively known as DNA damage response (DDR). The DDR orchestrates different cellular processes, such as DNA repair, senescence and apoptosis. Among the key factors of the DDR, the related proteins p53, p63 and p73, all belonging to the same family of transcription factors, play multiple relevant roles. Indeed, the members of this family are directly involved in the induction of cell cycle arrest that is necessary to allow the cells to repair. Alternatively, they can promote cell death in case of prolonged or irreparable DNA damage. They also take part in a more direct task by modulating the expression of core factors involved in the process of DNA repair or by directly interacting with them. In this review we will analyze the fundamental roles of the p53 family in the aging process through their multifaceted function in DDR.
KW - Aging
KW - DNA repair
KW - Homologous recombination
KW - Non homologous end joining
KW - p53
KW - p63
KW - p73
UR - http://www.scopus.com/inward/record.url?scp=84958177765&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958177765&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84958177765
VL - 7
SP - 1050
EP - 1065
JO - Aging
JF - Aging
SN - 1945-4589
IS - 12
ER -