DNA repair and aging: The impact of the p53 family

Sara Nicolai, Antonello Rossi, Nicola Di Daniele, Gerry Melino, Margherita Annicchiarico-Petruzzelli, Giuseppe Raschellà

Research output: Contribution to journalArticlepeer-review

Abstract

Cells are constantly exposed to endogenous and exogenous factors that threaten the integrity of their DNA. The maintenance of genome stability is of paramount importance in the prevention of both cancer and aging processes. To deal with DNA damage, cells put into operation a sophisticated and coordinated mechanism, collectively known as DNA damage response (DDR). The DDR orchestrates different cellular processes, such as DNA repair, senescence and apoptosis. Among the key factors of the DDR, the related proteins p53, p63 and p73, all belonging to the same family of transcription factors, play multiple relevant roles. Indeed, the members of this family are directly involved in the induction of cell cycle arrest that is necessary to allow the cells to repair. Alternatively, they can promote cell death in case of prolonged or irreparable DNA damage. They also take part in a more direct task by modulating the expression of core factors involved in the process of DNA repair or by directly interacting with them. In this review we will analyze the fundamental roles of the p53 family in the aging process through their multifaceted function in DDR.

Original languageEnglish
Pages (from-to)1050-1065
Number of pages16
JournalAging
Volume7
Issue number12
Publication statusPublished - 2015

Keywords

  • Aging
  • DNA repair
  • Homologous recombination
  • Non homologous end joining
  • p53
  • p63
  • p73

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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