DNA repair gene polymorphisms in non-small-cell lung cancer patients treated with first-line platinumcontaining chemotherapy

Eliana Rulli, Mirko Marabese, Sheila Piva, Lucia Bonomi, Elisa Caiola, Monica Ganzinelli

Research output: Contribution to journalArticle

Abstract

Purpose: Single nucleotide polymorphisms (SNPs) in the DNA repair genes are believed to contribute to the clinical outcome of patients receiving platinum-based chemotherapy. We investigated the impact of 2 SNPs of excision repair cross-complementation group 1 and 2 of xeroderma pigmentosum complementation group G on the outcome in patients with non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy. Methods: Between October 2007 and March 2012, we collected 374 blood samples from consecutive patients registered in the TAILOR trial. Four SNPs (rs11615, rs3212986, rs17655, rs1047768) were genotyped using realtime polymerase chain reaction. Results: The rs11615 polymorphism was associated with histotype (p = 0.0123). No other correlations were found with clinical variables or with EGFR or KRAS mutational status. None of the SNPs had any impact on overall survival or progression-free survival. Conclusions: The findings suggest that the investigated SNPs do not make any significant contribution to the outcome of NSCLC.

Original languageEnglish
Pages (from-to)367-375
Number of pages9
JournalTumori
Volume102
Issue number4
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • ERCC1
  • Non-small-cell lung cancer
  • Single nucleotide polymorphisms
  • XPG

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

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