DNA repair in lymphocytes from humans and rats with chronic iron overload

A. Pietrangelo, A. Cossarizza, D. Monti, E. Ventura, C. Franceschi

Research output: Contribution to journalArticle

Abstract

A marked reduction of the proliferative capability after a mitogenic stimulus and a dramatic decrease of the capacity to repair DNA damages were found in lymphocytes from iron overloaded rats. These immunological parameters were not significantly different from controls in peripheral blood lymphocytes from patients with primary iron overload: hereditary hemochromatosis and porphyria cutanea tarda. This discrepancy could be due to the accelerated modality of iron overload in the rat model and to the fact that rat lymphocytes were obtained from an highly iron repleted microenvironment (i.e. spleen). Our data indicate that iron overload can affect the structure and/or the function of cellular DNA thus offering new insights on the close association of iron overload conditions and cancer.

Original languageEnglish
Pages (from-to)698-704
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume154
Issue number2
DOIs
Publication statusPublished - Jul 29 1988

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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