DNA repair in normal and cancer stem cells, with special reference to the central nervous system

Research output: Contribution to journalArticlepeer-review

Abstract

Stem cells build and maintain organisms. Accordingly, they are particularly well-protected from damage to DNA and other cellular components. This feature becomes a serious drawback when stem cells transform and develop cancer, because they resist to radiation and chemotherapy. Various mechanisms ensure protection of stem cells. In normal stem cells enhanced DNA repair is often one of them. Whether the same holds for cancer stem cells still is an open question.

Original languageEnglish
Pages (from-to)854-866
Number of pages13
JournalCurrent Medicinal Chemistry
Volume16
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • Cancer
  • CD133
  • Differentiation
  • DNA repair
  • Stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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