Sintesi di DNA ed espressione dei recettori steroidei in cellule di carcinoma mammario umano.

Translated title of the contribution: Dna synthesis and expression of steroid receptors in cells of human breast carcinoma

G. Simone, A. Mangia, S. Petroni, F. Marzullo, A. Paradiso, F. Schittulli

Research output: Contribution to journalArticlepeer-review

Abstract

In order to observe receptor expression (ER and PgR) in human breast cancer cells during the S-phase of the cellular cycle, we evaluated 21 tumoral samples using a double labeling immunocytochemical-autoradiographic assay. In 16 of these we have verified that expression of ER and PgR is not influenced by incubation with 3H-Thymidine for 60 minutes. The results also demonstrated that receptor expression during the S-phase is more common in postmenopausal tumors and is principally dependent on percentages of ER+ (p <0.01) and PgR+ (p <0.01) cells; moreover, proliferative activity occurs almost exclusively in ER- (p = 0.003) and Pgr- (p = 0.001) cellular sub populations and the presence of PgR, but not of ER, is related to arrest of DNA synthesis (p = 0.02).

Translated title of the contributionDna synthesis and expression of steroid receptors in cells of human breast carcinoma
Original languageItalian
Pages (from-to)111-116
Number of pages6
JournalPathologica
Volume88
Issue number2
Publication statusPublished - Apr 1996

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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