TY - JOUR
T1 - Do animal models have clinical value?
AU - Schwartz, Peter J.
PY - 1998/3/19
Y1 - 1998/3/19
N2 - This article examines the efficacy of studying antiarrhythmic and antifibrillatory interventions using animal models. The importance of identifying appropriate animal models and comparing results from these studies to human clinical trials is discussed. Specific studies will be cited, the advantages/disadvantages of each design (i.e., internal control analysis factors, reproducibility of results, anesthetized vs conscious models) will be presented, and their ability or inability to predict clinical outcomes will be discussed.
AB - This article examines the efficacy of studying antiarrhythmic and antifibrillatory interventions using animal models. The importance of identifying appropriate animal models and comparing results from these studies to human clinical trials is discussed. Specific studies will be cited, the advantages/disadvantages of each design (i.e., internal control analysis factors, reproducibility of results, anesthetized vs conscious models) will be presented, and their ability or inability to predict clinical outcomes will be discussed.
UR - http://www.scopus.com/inward/record.url?scp=0032546403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032546403&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(98)00148-9
DO - 10.1016/S0002-9149(98)00148-9
M3 - Article
C2 - 9537218
AN - SCOPUS:0032546403
VL - 81
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 6 A
ER -