Do chemokines play a role in HIV-1 heterosexual transmission? Susceptibility to HIV infection

C. D'Ubaldo, D. Serraino, M. Peroni, G. Ippolito

Research output: Contribution to journalArticle

Abstract

The probability of HIV transmission depends on the infectiousness of the infected partner, the susceptibility of the healthy partner, and the biological characteristics of HIV strains. A substantial role is attributable to the individual HIV susceptibility, which is affected by immunological and genetic factors. Among genetic factors, the chemokine receptor CCR5 has been thoroughly studied. CCR5 is a co-receptor for fusion and entry of macrophagetropic variants of HIV-1, which are involved in sexual transmission. Consistent evidence shows that the absence of cell-surface expression of the HIV co-receptor CCR5, due to a homozygous 32 base pair deletion, renders individuals highly resistant to infection by macrophage-tropic HIV strains. Therefore, knowledge of this and of other genetic and Immunologic factors that affect HIV-1 transmission is essential in understanding HIV-1 entry into cells, developing strategies for combating HIV-1 transmission and spread, and implementing new models for HIV-1 therapies and, hopefully, vaccines.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume13
Issue number2
Publication statusPublished - 1999

Keywords

  • Chemokines
  • Heterosexual transmission
  • HIV
  • Host determinants
  • Resistance
  • Susceptibility

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

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