Do CSF levels of t-Tau, p-Tau and β1-42 amyloid correlate with dopaminergic system impairment in patients with a clinical diagnosis of Parkinson disease? A 123I-FP-CIT study in the early stages of the disease

Agostino Chiaravalloti, Alessandro Stefani, Alessandro Fiorentini, Annamaria Lacanfora, Paolo Stanzione, Orazio Schillaci

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate the relationships among cerebrospinal fluid (CSF) levels of t-Tau, p-Tau and Aβ1-42 amyloid peptide and 123I-FP-CIT uptake.

Conclusion: The results of our study suggest that the presynaptic dopaminergic system is more involved in Parkinson disease patients with lower t-Tau and p-Tau CSF values while values of Aβ1-42 amyloid peptide seems not to be related to nigrostriatal degeneration in our series.

Methods: The study included 58 subjects (31 men and 27 women, age 67 ± 9 years) with a clinical diagnosis of Parkinson disease diagnosed according to the United Kingdom Parkinson Disease Society Brain Bank criteria. All subjects underwent a CSF assay 28 ± 3 days before 123I-FP-CIT SPECT scanning. The relationships were evaluated by means of linear regression analysis and Pearson correlation.

Results: Striatal 123I-FP-CIT was positively related to both t-Tau and p-Tau CSF values with low levels of t-Tau and p-Tau being related to a low uptake of 123I-FP-CIT. In particular, differences with higher statistical significance were found for the striatum between the contralateral side and the side mainly affected on clinical examination (P <0.001). No significant relationships were found between Aβ1-42 amyloid peptide and 123I-FP-CIT binding.

Original languageEnglish
Pages (from-to)2137-2143
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume41
Issue number11
DOIs
Publication statusPublished - 2014

Keywords

  • Amyloid
  • DaTscan
  • p-Tau
  • Parkinson disease
  • t-Tau

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Fingerprint Dive into the research topics of 'Do CSF levels of t-Tau, p-Tau and β<sub>1-42</sub> amyloid correlate with dopaminergic system impairment in patients with a clinical diagnosis of Parkinson disease? A <sup>123</sup>I-FP-CIT study in the early stages of the disease'. Together they form a unique fingerprint.

Cite this