Do cyclodextrins bound to dextran microspheres act as sustained delivery systems of drugs? Paper dedicated to the 65th anniversary of «petru Poni» Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.

Marieta Constantin, Sanda Bucatariu, Valeria Harabagiu, Paolo Ascenzi, Gheorghe Fundueanu

Research output: Contribution to journalArticlepeer-review

Abstract

The use of cyclodextrins (CDs) for controlled delivery of drugs is largely presented in the literature. However, the question of whether CDs themselves linked to a polymeric network are able to sustain the release of drugs still persists. Here, CD immobilization within dextran microspheres is reported, and CD-dextran complexes were packed in a glass column and then, the retention time of different drugs and drug model compounds was determined by liquid chromatography. The release profiles of drugs and of drug model compounds (indole, 3-nitrophenol, p-hydroxybenzoic acid, diclofenac), characterized by different values of the retention time (high, moderate or low), were investigated. The release rates were quite high even for drugs that exhibit very high retention time (high association equilibrium constant). Moreover, the volume of the release fluid strongly influences the rate of drug release. As a whole, "the sink conditions" must be continuously maintained, since at each drug concentration in the release medium, equilibrium occurs between the free and the CD-bound drug.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume469
Issue number1
DOIs
Publication statusPublished - Jul 20 2014

Keywords

  • Association constant
  • Cyclodextrin
  • Drug release
  • Inclusion complex
  • Keywords
  • Liquid chromatography

ASJC Scopus subject areas

  • Pharmaceutical Science

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