Do dermatomyositis and polymyositis affect similar thigh muscles? A comparative MRI-based study

Nicolo Pipitone, Antonella Notarnicola, Gabriele Levrini, Lucia Spaggiari, Arnaldo Scardapane, Florenzo Iannone, Giovanni Lapadula, Pierpaolo Pattacini, Giulio Zuccoli, Carlo Salvarani

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVES: Dermatomyositis (DM) and polymyositis (PM) commonly cause weakness of the thigh muscles. However, it is debated whether DM and PM affect similar thigh muscles. Muscle oedema on fat-suppressed MRI sequences is thought to represent active inflammation. In this study, we aimed to assess which thigh muscle groups are preferentially inflamed in DM and PM, respectively, using short-tau inversion-recovery MRI sequences.

METHODS: We analysed 71 patients from 2 Rheumatology centres, 31 with DM and 40 with PM diagnosed according to the Bohan and Peter criteria. MRI oedema (1=present, 0=absent) was assessed bilaterally on fat-suppressed sequences in 17 pelvic floor and thigh muscles. An MRI oedema score (range 0-17) was calculated by adding the separate scores bilaterally and dividing them by two. Inter-rater variability was assessed by intraclass correlation coefficient. Fisher's exact test was used to compare binomial data.

RESULTS: Age and gender ratio were similar in patients with DM and PM. Disease duration (months, mean±SD) was shorter (20±31) in DM than in PM (53±69) (p=0.02). The intraclass correlation coefficient between the radiologists involved was 0.78. Muscle oedema was more common in DM than in PM except in the posterior thigh muscles. In particular, 68% of patients with DM had involvement of at least one anterior thigh muscle versus 38% of patients with PM (p=0.02).

CONCLUSIONS: Compared with PM, DM affects more thigh muscles, except those of the posterior compartment, which are equally involved in both disorders. These findings may be useful to target physiotherapy at the more frequently affected muscles.

Original languageEnglish
Pages (from-to)1098-1100
Number of pages3
JournalClinical and Experimental Rheumatology
Volume34
Issue number6
Publication statusPublished - Nov 1 2016

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Dermatomyositis
Thigh
Muscles
Edema
Polymyositis
Fats
Pelvic Floor
Muscle Weakness
Rheumatology
Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Pipitone, N., Notarnicola, A., Levrini, G., Spaggiari, L., Scardapane, A., Iannone, F., ... Salvarani, C. (2016). Do dermatomyositis and polymyositis affect similar thigh muscles? A comparative MRI-based study. Clinical and Experimental Rheumatology, 34(6), 1098-1100.

Do dermatomyositis and polymyositis affect similar thigh muscles? A comparative MRI-based study. / Pipitone, Nicolo; Notarnicola, Antonella; Levrini, Gabriele; Spaggiari, Lucia; Scardapane, Arnaldo; Iannone, Florenzo; Lapadula, Giovanni; Pattacini, Pierpaolo; Zuccoli, Giulio; Salvarani, Carlo.

In: Clinical and Experimental Rheumatology, Vol. 34, No. 6, 01.11.2016, p. 1098-1100.

Research output: Contribution to journalArticle

Pipitone, N, Notarnicola, A, Levrini, G, Spaggiari, L, Scardapane, A, Iannone, F, Lapadula, G, Pattacini, P, Zuccoli, G & Salvarani, C 2016, 'Do dermatomyositis and polymyositis affect similar thigh muscles? A comparative MRI-based study', Clinical and Experimental Rheumatology, vol. 34, no. 6, pp. 1098-1100.
Pipitone N, Notarnicola A, Levrini G, Spaggiari L, Scardapane A, Iannone F et al. Do dermatomyositis and polymyositis affect similar thigh muscles? A comparative MRI-based study. Clinical and Experimental Rheumatology. 2016 Nov 1;34(6):1098-1100.
Pipitone, Nicolo ; Notarnicola, Antonella ; Levrini, Gabriele ; Spaggiari, Lucia ; Scardapane, Arnaldo ; Iannone, Florenzo ; Lapadula, Giovanni ; Pattacini, Pierpaolo ; Zuccoli, Giulio ; Salvarani, Carlo. / Do dermatomyositis and polymyositis affect similar thigh muscles? A comparative MRI-based study. In: Clinical and Experimental Rheumatology. 2016 ; Vol. 34, No. 6. pp. 1098-1100.
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abstract = "OBJECTIVES: Dermatomyositis (DM) and polymyositis (PM) commonly cause weakness of the thigh muscles. However, it is debated whether DM and PM affect similar thigh muscles. Muscle oedema on fat-suppressed MRI sequences is thought to represent active inflammation. In this study, we aimed to assess which thigh muscle groups are preferentially inflamed in DM and PM, respectively, using short-tau inversion-recovery MRI sequences.METHODS: We analysed 71 patients from 2 Rheumatology centres, 31 with DM and 40 with PM diagnosed according to the Bohan and Peter criteria. MRI oedema (1=present, 0=absent) was assessed bilaterally on fat-suppressed sequences in 17 pelvic floor and thigh muscles. An MRI oedema score (range 0-17) was calculated by adding the separate scores bilaterally and dividing them by two. Inter-rater variability was assessed by intraclass correlation coefficient. Fisher's exact test was used to compare binomial data.RESULTS: Age and gender ratio were similar in patients with DM and PM. Disease duration (months, mean±SD) was shorter (20±31) in DM than in PM (53±69) (p=0.02). The intraclass correlation coefficient between the radiologists involved was 0.78. Muscle oedema was more common in DM than in PM except in the posterior thigh muscles. In particular, 68{\%} of patients with DM had involvement of at least one anterior thigh muscle versus 38{\%} of patients with PM (p=0.02).CONCLUSIONS: Compared with PM, DM affects more thigh muscles, except those of the posterior compartment, which are equally involved in both disorders. These findings may be useful to target physiotherapy at the more frequently affected muscles.",
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AU - Pipitone, Nicolo

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AU - Levrini, Gabriele

AU - Spaggiari, Lucia

AU - Scardapane, Arnaldo

AU - Iannone, Florenzo

AU - Lapadula, Giovanni

AU - Pattacini, Pierpaolo

AU - Zuccoli, Giulio

AU - Salvarani, Carlo

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N2 - OBJECTIVES: Dermatomyositis (DM) and polymyositis (PM) commonly cause weakness of the thigh muscles. However, it is debated whether DM and PM affect similar thigh muscles. Muscle oedema on fat-suppressed MRI sequences is thought to represent active inflammation. In this study, we aimed to assess which thigh muscle groups are preferentially inflamed in DM and PM, respectively, using short-tau inversion-recovery MRI sequences.METHODS: We analysed 71 patients from 2 Rheumatology centres, 31 with DM and 40 with PM diagnosed according to the Bohan and Peter criteria. MRI oedema (1=present, 0=absent) was assessed bilaterally on fat-suppressed sequences in 17 pelvic floor and thigh muscles. An MRI oedema score (range 0-17) was calculated by adding the separate scores bilaterally and dividing them by two. Inter-rater variability was assessed by intraclass correlation coefficient. Fisher's exact test was used to compare binomial data.RESULTS: Age and gender ratio were similar in patients with DM and PM. Disease duration (months, mean±SD) was shorter (20±31) in DM than in PM (53±69) (p=0.02). The intraclass correlation coefficient between the radiologists involved was 0.78. Muscle oedema was more common in DM than in PM except in the posterior thigh muscles. In particular, 68% of patients with DM had involvement of at least one anterior thigh muscle versus 38% of patients with PM (p=0.02).CONCLUSIONS: Compared with PM, DM affects more thigh muscles, except those of the posterior compartment, which are equally involved in both disorders. These findings may be useful to target physiotherapy at the more frequently affected muscles.

AB - OBJECTIVES: Dermatomyositis (DM) and polymyositis (PM) commonly cause weakness of the thigh muscles. However, it is debated whether DM and PM affect similar thigh muscles. Muscle oedema on fat-suppressed MRI sequences is thought to represent active inflammation. In this study, we aimed to assess which thigh muscle groups are preferentially inflamed in DM and PM, respectively, using short-tau inversion-recovery MRI sequences.METHODS: We analysed 71 patients from 2 Rheumatology centres, 31 with DM and 40 with PM diagnosed according to the Bohan and Peter criteria. MRI oedema (1=present, 0=absent) was assessed bilaterally on fat-suppressed sequences in 17 pelvic floor and thigh muscles. An MRI oedema score (range 0-17) was calculated by adding the separate scores bilaterally and dividing them by two. Inter-rater variability was assessed by intraclass correlation coefficient. Fisher's exact test was used to compare binomial data.RESULTS: Age and gender ratio were similar in patients with DM and PM. Disease duration (months, mean±SD) was shorter (20±31) in DM than in PM (53±69) (p=0.02). The intraclass correlation coefficient between the radiologists involved was 0.78. Muscle oedema was more common in DM than in PM except in the posterior thigh muscles. In particular, 68% of patients with DM had involvement of at least one anterior thigh muscle versus 38% of patients with PM (p=0.02).CONCLUSIONS: Compared with PM, DM affects more thigh muscles, except those of the posterior compartment, which are equally involved in both disorders. These findings may be useful to target physiotherapy at the more frequently affected muscles.

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