Do differences in delivery room intubation explain different rates of bronchopulmonary dysplasia between hospitals?

Luigi Gagliardi, Roberto Bellù, Gianluca Lista, Rinaldo Zanini, G. Compagnoni, F. Mosca, S. Martinelli, G. Chirico, S. Santucci, M. L. Caccamo, M. Maccabruni, M. Stronati, G. Rondini, M. Agosti, L. A. Magni, G. Moro, P. Tagliabue, G. Barera, D. Merazzi, A. CavazzaA. Brunelli, M. Battaglioli, F. Tandoi, D. Cella, G. F. Perotti, M. Pelti, I. Stucchi, F. Frisone, A. Avanzini, P. Bastrenta, G. Iacono, F. Pontiggia, A. Cotta-Ramusino, F. Strano, P. Fontana, M. Franco, L. Rossi, G. Calciolari, G. Citterio, R. Rovelli, A. Poloniato, G. P. Gancia, C. Costato, R. Germani, S. Barp, R. Crossignani, N. Siliprandi, C. Borroni, M. L. Ventura, L. Abbiati, S. Giardinetti, L. Leva, M. Fusi, M. Bellasio

Research output: Contribution to journalArticlepeer-review


Objective: To investigate whether the wide variation in the frequency of bronchopulmonary dysplasia (BPD) between hospitals is due to differences in delivery room intubation rates. Methods: Data on 1260 infants of birth weight 24 h differed significantly between hospitals. Centres with high delivery room intubation rates had higher ventilation and BPD rates. Hospitals ventilating more often also did so for a longer time. Although delivery room intubation was associated with BPD in unadjusted analyses, neither delivery room intubation nor brief (24 h: adjusted OR (aOR) 2.4; >7 days: aOR 14.9), male sex (aOR 1.7), being small for gestational age (SGA; aOR 4.3) and late-onset sepsis (aOR 2.2). After taking into account these variables/procedures, centre differences remained significant but explained only about 5% of variance. Conclusions: Differences in BPD frequency between hospitals are explained by differences in procedures, chiefly mechanical ventilation, rather than by differences in initial management or case mix. Delivery room intubation and brief mechanical ventilation did not increase BPD risk.

Original languageEnglish
JournalArchives of Disease in Childhood: Fetal and Neonatal Edition
Issue number1
Publication statusPublished - Jan 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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