Do instrumental activities of daily living predict dementia at 1- and 2-year follow-up? Findings from the development of screening guidelines and diagnostic criteria for predementia Alzheimer's disease study

Sietske A M Sikkes, Pieter Jelle Visser, Dirk L. Knol, Elly S M De Lange-De Klerk, Magda Tsolaki, Giovani B. Frisoni, Flavio Nobili, Luiza Spiru, Anne Sophie Rigaud, Lutz Frölich, Marcel Olde Rikkert, Hilkka Soininen, Jacques Touchon, Gordon Wilcock, Mercè Boada, Harald Hampel, Roger Bullock, Bruno Vellas, Yolande A L Pijnenburg, Philip ScheltensFrans R. Verhey, Bernard M J Uitdehaag

Research output: Contribution to journalArticle

Abstract

Objectives To investigate whether problems in instrumental activities of daily living (IADL) can add to conventionally used clinical measurements in helping to predict a diagnosis of dementia at 1- and 2-year follow-up. Design Multicenter prospective cohort study. Setting Memory clinics in Europe. Participants Individuals aged 55 and older without dementia. Measurements IADLs were measured using pooled activities from five informant-based questionnaires. Structural equation modeling (SEM) was used to investigate the relation between IADLs and dementia. Age, sex, education, depression, and cognitive measures (Mini-Mental State Examination and verbal memory) were included in the model. Results Five hundred thirty-one participants had baseline and 1-year follow-up assessments; 69 (13.0%) of these had developed dementia at 1-year follow-up. At 2-year follow-up, 481 participants were seen, of whom 100 (20.8%) had developed dementia. Participants with IADL disabilities at baseline had a higher conversion rate (24.4%) than participants without IADL disabilities (16.7%) (chi-square = 4.28, degrees of freedom = 1, P =.04). SEM showed that IADL disability could help predict dementia in addition to the measured variables at 1-year follow-up (odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.51-3.13) and 2-year follow-up (OR = 2.11, 95% CI = 1.33-3.33). Conclusion IADL disability is a useful addition to the diagnostic process in a memory clinic setting, indicating who is at higher risk of developing dementia at 1- and 2-year follow-up.

Original languageEnglish
Pages (from-to)2273-2281
Number of pages9
JournalJournal of the American Geriatrics Society
Volume59
Issue number12
DOIs
Publication statusPublished - Dec 2011

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Keywords

  • activities of daily living
  • Alzheimer's disease
  • everyday functioning
  • memory
  • mild cognitive impairment
  • structural equation modeling

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Sikkes, S. A. M., Visser, P. J., Knol, D. L., De Lange-De Klerk, E. S. M., Tsolaki, M., Frisoni, G. B., Nobili, F., Spiru, L., Rigaud, A. S., Frölich, L., Rikkert, M. O., Soininen, H., Touchon, J., Wilcock, G., Boada, M., Hampel, H., Bullock, R., Vellas, B., Pijnenburg, Y. A. L., ... Uitdehaag, B. M. J. (2011). Do instrumental activities of daily living predict dementia at 1- and 2-year follow-up? Findings from the development of screening guidelines and diagnostic criteria for predementia Alzheimer's disease study. Journal of the American Geriatrics Society, 59(12), 2273-2281. https://doi.org/10.1111/j.1532-5415.2011.03732.x