Do seizures promote epileptogenesis and cause cognitive decline?

Giuliano Avanzini

Research output: Contribution to journalArticlepeer-review


The assumption that repeated seizures may induce a progression of epilepsies towards an intractable condition and a cognitive decline does not hold true for idiopathic epilepsies but can only be considered for mesial temporal lobe epilepsy and epileptic encephalopathies. The available evidence leads to the conclusion that in most cases the epilepsy worsening and cognitive decline are due to the progression of the underlying pathology or to its interference with the developmental programme, the notable exception being the epileptic encephalopathies with continuous epileptic activity during sleep.

Original languageEnglish
Pages (from-to)120-121
Number of pages2
JournalEuropean Neurological Review
Issue number2
Publication statusPublished - 2014


  • Epilepsy progression
  • Epileptic encephalopathies
  • Epileptogenesis
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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