TY - JOUR
T1 - Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
AU - Pelicci, Pier Giuseppe
PY - 2004/1
Y1 - 2004/1
N2 - Stem/progenitor cells ensure tissue and organism homeostasis and might represent a frequent target of transformation. Although these cells are potentially immortal, their life span is restrained by signaling pathways (p19-p53; p16-Rb) that are activated by DNA damage (telomere dysfunction, environmental stresses) and lead to senescence or apoptosis. Execution of these checkpoint programs might lead to stem cell depletion and organism aging, while their inactivation contributes to tumor formation.
AB - Stem/progenitor cells ensure tissue and organism homeostasis and might represent a frequent target of transformation. Although these cells are potentially immortal, their life span is restrained by signaling pathways (p19-p53; p16-Rb) that are activated by DNA damage (telomere dysfunction, environmental stresses) and lead to senescence or apoptosis. Execution of these checkpoint programs might lead to stem cell depletion and organism aging, while their inactivation contributes to tumor formation.
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U2 - 10.1172/JCI200420750
DO - 10.1172/JCI200420750
M3 - Article
C2 - 14702099
AN - SCOPUS:1542781658
VL - 113
SP - 4
EP - 7
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 1
ER -