Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?

Research output: Contribution to journalArticlepeer-review

Abstract

Stem/progenitor cells ensure tissue and organism homeostasis and might represent a frequent target of transformation. Although these cells are potentially immortal, their life span is restrained by signaling pathways (p19-p53; p16-Rb) that are activated by DNA damage (telomere dysfunction, environmental stresses) and lead to senescence or apoptosis. Execution of these checkpoint programs might lead to stem cell depletion and organism aging, while their inactivation contributes to tumor formation.

Original languageEnglish
Pages (from-to)4-7
Number of pages4
JournalJournal of Clinical Investigation
Volume113
Issue number1
DOIs
Publication statusPublished - Jan 2004

ASJC Scopus subject areas

  • Medicine(all)

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