TY - JOUR
T1 - Do we need oxytocin to treat schizophrenia? A randomized clinical trial
AU - Dagani, Jessica
AU - Sisti, Davide
AU - Abelli, Marianna
AU - Di Paolo, Luca
AU - Pini, Stefano
AU - Raimondi, Sara
AU - Rocchi, Marco B.
AU - Saviotti, Francesco M.
AU - Scocco, Paolo
AU - Totaro, Stefano
AU - Balestrieri, Matteo
AU - de Girolamo, Giovanni
PY - 2016/4
Y1 - 2016/4
N2 - Background: Schizophrenia is a disabling complex mental disorder and despite all available treatment, many patients unfortunately remain partial- or non-responders. A large body of research has shown that oxytocin is an important prosocial peptide and there is initial evidence that the central oxytocin system is altered in several mental disorders. The aim of this study was to test the efficacy of oxytocin, as augmentation therapy, in a sample of patients with schizophrenia. Methods: We conducted an 8-month randomized, double-blind, controlled trial with a crossover design. We wanted to test the hypothesis that intranasal oxytocin could reduce symptoms in 32 patients with schizophrenia aged 18-45 with short-medium illness duration (
AB - Background: Schizophrenia is a disabling complex mental disorder and despite all available treatment, many patients unfortunately remain partial- or non-responders. A large body of research has shown that oxytocin is an important prosocial peptide and there is initial evidence that the central oxytocin system is altered in several mental disorders. The aim of this study was to test the efficacy of oxytocin, as augmentation therapy, in a sample of patients with schizophrenia. Methods: We conducted an 8-month randomized, double-blind, controlled trial with a crossover design. We wanted to test the hypothesis that intranasal oxytocin could reduce symptoms in 32 patients with schizophrenia aged 18-45 with short-medium illness duration (
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U2 - 10.1016/j.schres.2016.02.011
DO - 10.1016/j.schres.2016.02.011
M3 - Article
AN - SCOPUS:84957895177
VL - 172
SP - 158
EP - 164
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -