Abstract
Purpose We analyzed the distinct clinicopathological features and prognosis of patients with renal cell carcinoma age 40 years or less compared to a reference group of patients 60 to 70 years old. Materials and Methods Overall 2,572 patients retrieved from a multicenter international database comprised of 6,234 patients with surgically treated renal cell carcinoma were included in this retrospective study. Clinical and histopathological features of 297 patients 40 years old or younger (4.8%) were compared to those of 2,275 patients (36.5%) 60 to 70 years old, who served as the reference group. Median followup was 59 months. The impact of young age and further parameters on disease specific mortality and all cause mortality was evaluated by multivariate Cox proportional hazards regression analyses. Results Young patients more frequently underwent nephron sparing surgery (27% vs 20%, p = 0.008) and regional lymph node dissection compared to older patients (38% vs 32%, p = 0.025). Organ confined tumor stage (81% vs 70%, p
| Original language | English |
|---|---|
| Pages (from-to) | 310-315 |
| Number of pages | 6 |
| Journal | Journal of Urology |
| Volume | 191 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2014 |
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Keywords
- age factors
- carcinoma
- neoplasms by histologic type
- nephrectomy
- outcome assessment
- renal cell
ASJC Scopus subject areas
- Urology
Cite this
Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational corona database. / Aziz, Atiqullah; May, Matthias; Zigeuner, Richard; Pichler, Martin; Chromecki, Thomas; Cindolo, Luca; Schips, Luigi; De Cobelli, Ottavio; Rocco, Bernardo; De Nunzio, Cosimo; Tubaro, Andrea; Coman, Ioan; Truss, Michael; Dalpiaz, Orietta; Hoschke, Bernd; Gilfrich, Christian; Feciche, Bogdan; Fenske, Fabian; Sountoulides, Petros; Figenshau, Robert S.; Madison, Kerry; Sánchez-Chapado, Manuel; Del Carmen Santiago Martin, Maria; Wieland, Wolf F.; Salzano, Luigi; Lotrecchiano, Giuseppe; Waidelich, Raphaela; Stief, Christian; Brookman-May, Sabine.
In: Journal of Urology, Vol. 191, No. 2, 02.2014, p. 310-315.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Do young patients with renal cell carcinoma feature a distinct outcome after surgery? A comparative analysis of patient age based on the multinational corona database
AU - Aziz, Atiqullah
AU - May, Matthias
AU - Zigeuner, Richard
AU - Pichler, Martin
AU - Chromecki, Thomas
AU - Cindolo, Luca
AU - Schips, Luigi
AU - De Cobelli, Ottavio
AU - Rocco, Bernardo
AU - De Nunzio, Cosimo
AU - Tubaro, Andrea
AU - Coman, Ioan
AU - Truss, Michael
AU - Dalpiaz, Orietta
AU - Hoschke, Bernd
AU - Gilfrich, Christian
AU - Feciche, Bogdan
AU - Fenske, Fabian
AU - Sountoulides, Petros
AU - Figenshau, Robert S.
AU - Madison, Kerry
AU - Sánchez-Chapado, Manuel
AU - Del Carmen Santiago Martin, Maria
AU - Wieland, Wolf F.
AU - Salzano, Luigi
AU - Lotrecchiano, Giuseppe
AU - Waidelich, Raphaela
AU - Stief, Christian
AU - Brookman-May, Sabine
PY - 2014/2
Y1 - 2014/2
N2 - Purpose We analyzed the distinct clinicopathological features and prognosis of patients with renal cell carcinoma age 40 years or less compared to a reference group of patients 60 to 70 years old. Materials and Methods Overall 2,572 patients retrieved from a multicenter international database comprised of 6,234 patients with surgically treated renal cell carcinoma were included in this retrospective study. Clinical and histopathological features of 297 patients 40 years old or younger (4.8%) were compared to those of 2,275 patients (36.5%) 60 to 70 years old, who served as the reference group. Median followup was 59 months. The impact of young age and further parameters on disease specific mortality and all cause mortality was evaluated by multivariate Cox proportional hazards regression analyses. Results Young patients more frequently underwent nephron sparing surgery (27% vs 20%, p = 0.008) and regional lymph node dissection compared to older patients (38% vs 32%, p = 0.025). Organ confined tumor stage (81% vs 70%, p
AB - Purpose We analyzed the distinct clinicopathological features and prognosis of patients with renal cell carcinoma age 40 years or less compared to a reference group of patients 60 to 70 years old. Materials and Methods Overall 2,572 patients retrieved from a multicenter international database comprised of 6,234 patients with surgically treated renal cell carcinoma were included in this retrospective study. Clinical and histopathological features of 297 patients 40 years old or younger (4.8%) were compared to those of 2,275 patients (36.5%) 60 to 70 years old, who served as the reference group. Median followup was 59 months. The impact of young age and further parameters on disease specific mortality and all cause mortality was evaluated by multivariate Cox proportional hazards regression analyses. Results Young patients more frequently underwent nephron sparing surgery (27% vs 20%, p = 0.008) and regional lymph node dissection compared to older patients (38% vs 32%, p = 0.025). Organ confined tumor stage (81% vs 70%, p
KW - age factors
KW - carcinoma
KW - neoplasms by histologic type
KW - nephrectomy
KW - outcome assessment
KW - renal cell
UR - http://www.scopus.com/inward/record.url?scp=84891952366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891952366&partnerID=8YFLogxK
U2 - 10.1016/j.juro.2013.08.021
DO - 10.1016/j.juro.2013.08.021
M3 - Article
VL - 191
SP - 310
EP - 315
JO - Journal of Urology
JF - Journal of Urology
SN - 0022-5347
IS - 2
ER -