Docetaxel followed by gemcitabine in the treatment of advanced non-small cell lung cancer: A phase I study

Giovanni Luca Frassineti, Toni Ibrahim, Wainer Zoli, Manuela Monti, Luca Ricotti, Oriana Nanni, Dino Amadori

Research output: Contribution to journalArticle

Abstract

Aims and background: Based on the results of a preclinical study, a phase I trial was conducted to evaluate the feasibility of administering docetaxel followed by gemcitabine in nonsmall cell lung cancer patients. Study design: Sixteen patients with advanced non-small cell lung cancer (stages III B-IV) were treated on the 1 st day with docetaxel and on the 8 th day with gemcitabine. Treatment was repeated every three weeks for a maximum of six cycles. Five groups received docetaxel/gemcitabine (mg/m 2): 50/800, 60/800, 60/900, 60/1,000, 70/1,000. All patients and 57 cycles were assessed for toxicity. Results: The most important side effects were grade IV neutropenia in 4 patients (2 at the 60/1000 level and 2 at the 70/1000 level) and grade III leukopenia and neutropenia without fever in 4 and 6 patients, respectively. Maximum tolerated dose was not reached. Conclusions: The sequence docetaxel→ gemcitabine appears well tolerated and easy to administer. For this reason, a phase II study is ongoing to fully assess its antitumor activity.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalTumori
Volume88
Issue number2
Publication statusPublished - 2002

Keywords

  • Docetaxel
  • Gemcitabine
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Cancer Research

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