Docetaxel neuropathy: A distal axonopathy

Raffaella Fazio, Angelo Quattrini, Angelo Bolognesi, Gianni Bordogna, Eugenio Villa, Stefano Previtali, Nicola Canal, Raffaello Nemni

Research output: Contribution to journalArticle

Abstract

Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal.

Original languageEnglish
Pages (from-to)651-653
Number of pages3
JournalActa Neuropathologica
Volume98
Issue number6
DOIs
Publication statusPublished - Dec 1999

Keywords

  • Docetaxel
  • Neuropathy
  • Neurotoxicity
  • Paclitaxel
  • Peripheral nerves

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

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  • Cite this

    Fazio, R., Quattrini, A., Bolognesi, A., Bordogna, G., Villa, E., Previtali, S., Canal, N., & Nemni, R. (1999). Docetaxel neuropathy: A distal axonopathy. Acta Neuropathologica, 98(6), 651-653. https://doi.org/10.1007/s004010051132