Docetaxel plus epidoxorubicin as neoadjuvant treatment in patients with large operable or locally advanced carcinoma of the breast: A single-center, phase II study

Andrea De Matteis, Francesco Nuzzo, Giuseppe D'Aiuto, Vincenzo Labonia, Gabriella Landi, Emanuela Rossi, Angelo Antonio Mastro, Gerardo Botti, Ermelinda De Maio, Francesco Perrone

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND. The objective of this study was to test the activity and toxicity of epirubicin plus docetaxel as primary chemotherapy for women with large, operable (T2; > 3 cm) or locally advanced (Stage III) breast carcinoma, including patients with inflammatory breast carcinoma. METHODS. In this single-center, open-label, single-stage, Phase II trial, epirubicin (75 mg/m2; intravenous bolus) followed by docetaxel (80 mg/m2; 1-hour intravenous infusion) was administered on Day 1 of each cycle for four cycles. RESULTS. Nine of 30 patients (30%) had inflammatory breast carcinoma. Twenty-three patients (76.7%; 95% confidence interval, 57.7-90.1) had a clinical objective response that was complete in 6 patients (20%). Twenty-seven patients (90%) underwent surgery that was conservative in 5 patients (16.7%). Pathologic response evaluation revealed four complete responses (13.3%; 95% confidence interval, 3.8-30.7). Grade 4 neutropenia was recorded in 80.0% of patients, and febrile neutropenia was recorded in one-third of patients. Anemia and thrombocytopenia were never severe. Other side effects were diarrhea (26.6%), oral mucositis (43.3%), and emesis (26.6%). CONCLUSIONS. Neoadjuvant chemotherapy with epirubicin plus docetaxel was a feasible treatment and was active in an unfavorable series of patients with locally advanced breast carcinoma, including patients with inflammatory breast carcinoma.

Original languageEnglish
Pages (from-to)895-901
Number of pages7
JournalCancer
Volume94
Issue number4
DOIs
Publication statusPublished - Feb 15 2002

Keywords

  • Breast carcinoma
  • Docetaxel
  • Epidoxorubicin
  • Neoadjuvant chemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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