TY - JOUR
T1 - Docetaxel plus epidoxorubicin as neoadjuvant treatment in patients with large operable or locally advanced carcinoma of the breast
T2 - A single-center, phase II study
AU - De Matteis, Andrea
AU - Nuzzo, Francesco
AU - D'Aiuto, Giuseppe
AU - Labonia, Vincenzo
AU - Landi, Gabriella
AU - Rossi, Emanuela
AU - Mastro, Angelo Antonio
AU - Botti, Gerardo
AU - De Maio, Ermelinda
AU - Perrone, Francesco
PY - 2002/2/15
Y1 - 2002/2/15
N2 - BACKGROUND. The objective of this study was to test the activity and toxicity of epirubicin plus docetaxel as primary chemotherapy for women with large, operable (T2; > 3 cm) or locally advanced (Stage III) breast carcinoma, including patients with inflammatory breast carcinoma. METHODS. In this single-center, open-label, single-stage, Phase II trial, epirubicin (75 mg/m2; intravenous bolus) followed by docetaxel (80 mg/m2; 1-hour intravenous infusion) was administered on Day 1 of each cycle for four cycles. RESULTS. Nine of 30 patients (30%) had inflammatory breast carcinoma. Twenty-three patients (76.7%; 95% confidence interval, 57.7-90.1) had a clinical objective response that was complete in 6 patients (20%). Twenty-seven patients (90%) underwent surgery that was conservative in 5 patients (16.7%). Pathologic response evaluation revealed four complete responses (13.3%; 95% confidence interval, 3.8-30.7). Grade 4 neutropenia was recorded in 80.0% of patients, and febrile neutropenia was recorded in one-third of patients. Anemia and thrombocytopenia were never severe. Other side effects were diarrhea (26.6%), oral mucositis (43.3%), and emesis (26.6%). CONCLUSIONS. Neoadjuvant chemotherapy with epirubicin plus docetaxel was a feasible treatment and was active in an unfavorable series of patients with locally advanced breast carcinoma, including patients with inflammatory breast carcinoma.
AB - BACKGROUND. The objective of this study was to test the activity and toxicity of epirubicin plus docetaxel as primary chemotherapy for women with large, operable (T2; > 3 cm) or locally advanced (Stage III) breast carcinoma, including patients with inflammatory breast carcinoma. METHODS. In this single-center, open-label, single-stage, Phase II trial, epirubicin (75 mg/m2; intravenous bolus) followed by docetaxel (80 mg/m2; 1-hour intravenous infusion) was administered on Day 1 of each cycle for four cycles. RESULTS. Nine of 30 patients (30%) had inflammatory breast carcinoma. Twenty-three patients (76.7%; 95% confidence interval, 57.7-90.1) had a clinical objective response that was complete in 6 patients (20%). Twenty-seven patients (90%) underwent surgery that was conservative in 5 patients (16.7%). Pathologic response evaluation revealed four complete responses (13.3%; 95% confidence interval, 3.8-30.7). Grade 4 neutropenia was recorded in 80.0% of patients, and febrile neutropenia was recorded in one-third of patients. Anemia and thrombocytopenia were never severe. Other side effects were diarrhea (26.6%), oral mucositis (43.3%), and emesis (26.6%). CONCLUSIONS. Neoadjuvant chemotherapy with epirubicin plus docetaxel was a feasible treatment and was active in an unfavorable series of patients with locally advanced breast carcinoma, including patients with inflammatory breast carcinoma.
KW - Breast carcinoma
KW - Docetaxel
KW - Epidoxorubicin
KW - Neoadjuvant chemotherapy
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U2 - 10.1002/cncr.20335
DO - 10.1002/cncr.20335
M3 - Article
C2 - 11920456
AN - SCOPUS:0037083497
VL - 94
SP - 895
EP - 901
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 4
ER -