Does ability to walk reflect general functionality in inflammatory neuropathies?

Thomas H P Draak, Kenneth C. Gorson, Els K. Vanhoutte, Sonja I. Van Nes, Pieter A. Van Doorn, David R. Cornblath, Leonard H. Van Den Berg, Catharina G. Faber, Ingemar S J Merkies, A. A. Barreira, D. Bennett, F. Bombelli, Vera Bril, A. Campanella, Elisabeth Aviva Cats, David R. Cornblath, R. Costa, M. De Visser, G. Devigili, P. A. van DoornCatharina G. Faber, J. Franques, Francesca Gallia, Kenneth C. Gorson, R. D M Hadden, A. F. Hahn, R. A C Hughes, I. Illa, Hans Katzberg, G. Lauria, J. M. Léger, R. A. Lewis, Michael P T Lunn, I. S J Merkies, Eduardo Nobile-Orazio, Nicolette C. Notermans, L. Padua, J. Pouget, L. Querol, J. Raaphorst, Mary M. Reilly, Leonard H. Van Den Berg, Peter Y K Van Den Bergh, Anneke J. Van Der Kooi, W. Ludo Van Der Pol, Sonja I. Van Nes, I. N. van Schaik, PeriNomS Study Group

Research output: Contribution to journalArticle

Abstract

The “ability to walk” is considered a benchmark for good clinical recovery and prognosis, particularly in patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, it has never been determined whether being “able to walk” represents general functionality. The purpose of this study was to examine whether the ability to walk outside independently reflects general functional improvement in patients with GBS, CIDP, and gammopathy-related neuropathy (MGUSP). A total of 137 patients with newly diagnosed (or relapsing) GBS (55), CIDP (59), and MGUSP (23) were serially examined (1-year). Predefined arbitrary cut-offs (so-called patients' Functional-Acceptable-Clinical-Thresholds [FACTs]) were taken at the 50th, 75th, and 90th percentile of the Inflammatory-Rasch-built-Overall-Disability-Scale (I-RODS©). We determined the proportion of patients able to walk outside independently that reached the postulated cut-offs. A mean total of 85%, 39%, and 12% of all patients able to walk reached 50th, 75th, and 90th percentile thresholds, respectively. These findings were not neuropathy type related. Our findings show that assessing only one construct of functionality (e.g., walking ability) does not reflect the full scope of daily/social functional deficits perceived by patients. The ability to walk shows a patient is doing better, but not necessarily doing well. The I-RODS© bypasses these limitations.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
JournalJournal of the Peripheral Nervous System
Volume21
Issue number2
DOIs
Publication statusPublished - 2016

Fingerprint

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Benchmarking
Walking

Keywords

  • inflammatory neuropathies
  • outcome research

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Draak, T. H. P., Gorson, K. C., Vanhoutte, E. K., Van Nes, S. I., Van Doorn, P. A., Cornblath, D. R., ... PeriNomS Study Group (2016). Does ability to walk reflect general functionality in inflammatory neuropathies? Journal of the Peripheral Nervous System, 21(2), 74-81. https://doi.org/10.1111/jns.12167

Does ability to walk reflect general functionality in inflammatory neuropathies? / Draak, Thomas H P; Gorson, Kenneth C.; Vanhoutte, Els K.; Van Nes, Sonja I.; Van Doorn, Pieter A.; Cornblath, David R.; Van Den Berg, Leonard H.; Faber, Catharina G.; Merkies, Ingemar S J; Barreira, A. A.; Bennett, D.; Bombelli, F.; Bril, Vera; Campanella, A.; Cats, Elisabeth Aviva; Cornblath, David R.; Costa, R.; De Visser, M.; Devigili, G.; van Doorn, P. A.; Faber, Catharina G.; Franques, J.; Gallia, Francesca; Gorson, Kenneth C.; Hadden, R. D M; Hahn, A. F.; Hughes, R. A C; Illa, I.; Katzberg, Hans; Lauria, G.; Léger, J. M.; Lewis, R. A.; Lunn, Michael P T; Merkies, I. S J; Nobile-Orazio, Eduardo; Notermans, Nicolette C.; Padua, L.; Pouget, J.; Querol, L.; Raaphorst, J.; Reilly, Mary M.; Van Den Berg, Leonard H.; Van Den Bergh, Peter Y K; Van Der Kooi, Anneke J.; Van Der Pol, W. Ludo; Van Nes, Sonja I.; van Schaik, I. N.; PeriNomS Study Group.

In: Journal of the Peripheral Nervous System, Vol. 21, No. 2, 2016, p. 74-81.

Research output: Contribution to journalArticle

Draak, THP, Gorson, KC, Vanhoutte, EK, Van Nes, SI, Van Doorn, PA, Cornblath, DR, Van Den Berg, LH, Faber, CG, Merkies, ISJ, Barreira, AA, Bennett, D, Bombelli, F, Bril, V, Campanella, A, Cats, EA, Cornblath, DR, Costa, R, De Visser, M, Devigili, G, van Doorn, PA, Faber, CG, Franques, J, Gallia, F, Gorson, KC, Hadden, RDM, Hahn, AF, Hughes, RAC, Illa, I, Katzberg, H, Lauria, G, Léger, JM, Lewis, RA, Lunn, MPT, Merkies, ISJ, Nobile-Orazio, E, Notermans, NC, Padua, L, Pouget, J, Querol, L, Raaphorst, J, Reilly, MM, Van Den Berg, LH, Van Den Bergh, PYK, Van Der Kooi, AJ, Van Der Pol, WL, Van Nes, SI, van Schaik, IN & PeriNomS Study Group 2016, 'Does ability to walk reflect general functionality in inflammatory neuropathies?', Journal of the Peripheral Nervous System, vol. 21, no. 2, pp. 74-81. https://doi.org/10.1111/jns.12167
Draak THP, Gorson KC, Vanhoutte EK, Van Nes SI, Van Doorn PA, Cornblath DR et al. Does ability to walk reflect general functionality in inflammatory neuropathies? Journal of the Peripheral Nervous System. 2016;21(2):74-81. https://doi.org/10.1111/jns.12167
Draak, Thomas H P ; Gorson, Kenneth C. ; Vanhoutte, Els K. ; Van Nes, Sonja I. ; Van Doorn, Pieter A. ; Cornblath, David R. ; Van Den Berg, Leonard H. ; Faber, Catharina G. ; Merkies, Ingemar S J ; Barreira, A. A. ; Bennett, D. ; Bombelli, F. ; Bril, Vera ; Campanella, A. ; Cats, Elisabeth Aviva ; Cornblath, David R. ; Costa, R. ; De Visser, M. ; Devigili, G. ; van Doorn, P. A. ; Faber, Catharina G. ; Franques, J. ; Gallia, Francesca ; Gorson, Kenneth C. ; Hadden, R. D M ; Hahn, A. F. ; Hughes, R. A C ; Illa, I. ; Katzberg, Hans ; Lauria, G. ; Léger, J. M. ; Lewis, R. A. ; Lunn, Michael P T ; Merkies, I. S J ; Nobile-Orazio, Eduardo ; Notermans, Nicolette C. ; Padua, L. ; Pouget, J. ; Querol, L. ; Raaphorst, J. ; Reilly, Mary M. ; Van Den Berg, Leonard H. ; Van Den Bergh, Peter Y K ; Van Der Kooi, Anneke J. ; Van Der Pol, W. Ludo ; Van Nes, Sonja I. ; van Schaik, I. N. ; PeriNomS Study Group. / Does ability to walk reflect general functionality in inflammatory neuropathies?. In: Journal of the Peripheral Nervous System. 2016 ; Vol. 21, No. 2. pp. 74-81.
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