TY - JOUR
T1 - Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?
AU - Participants, Italian Dystonia Registry
AU - Defazio, Giovanni
AU - Fabbrini, Giovanni
AU - Erro, Roberto
AU - Albanese, Alberto
AU - Barone, Paolo
AU - Zibetti, Maurizio
AU - Esposito, Marcello
AU - Pellicciari, Roberta
AU - Avanzino, Laura
AU - Bono, Francesco
AU - Eleopra, Roberto
AU - Bertolasi, Laura
AU - Altavista, Maria Concetta
AU - Cotelli, Maria Sofia
AU - Ceravolo, Roberto
AU - Scaglione, Cesa
AU - Bentivoglio, Anna Rita
AU - Cossu, Giovanni
AU - Coletti Moja, Mario
AU - Girlanda, Paolo
AU - Misceo, Salvatore
AU - Pisani, Antonio
AU - Mascia, Marcello Mario
AU - Ercoli, Tommaso
AU - Tinazzi, Michele
AU - Maderna, Luca
AU - Minafra, Brigida
AU - Magistrelli, Luca
AU - Romano, Marcello
AU - Aguggia, Marco
AU - Tambasco, Nicola
AU - Castagna, Anna
AU - Cassano, Daniela
AU - Berardelli, Alfredo
N1 - Copyright © 2020. Published by Elsevier Ltd.
PY - 2020/1/13
Y1 - 2020/1/13
N2 - BACKGROUND: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia.MATERIALS AND METHODS: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia.RESULTS: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development.DISCUSSION AND CONCLUSION: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.
AB - BACKGROUND: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia.MATERIALS AND METHODS: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia.RESULTS: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development.DISCUSSION AND CONCLUSION: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.
U2 - 10.1016/j.parkreldis.2020.01.002
DO - 10.1016/j.parkreldis.2020.01.002
M3 - Article
VL - 71
SP - 40
EP - 43
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
ER -