Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?

Italian Dystonia Registry Participants, Giovanni Defazio, Giovanni Fabbrini, Roberto Erro, Alberto Albanese, Paolo Barone, Maurizio Zibetti, Marcello Esposito, Roberta Pellicciari, Laura Avanzino, Francesco Bono, Roberto Eleopra, Laura Bertolasi, Maria Concetta Altavista, Maria Sofia Cotelli, Roberto Ceravolo, Cesa Scaglione, Anna Rita Bentivoglio, Giovanni Cossu, Mario Coletti MojaPaolo Girlanda, Salvatore Misceo, Antonio Pisani, Marcello Mario Mascia, Tommaso Ercoli, Michele Tinazzi, Luca Maderna, Brigida Minafra, Luca Magistrelli, Marcello Romano, Marco Aguggia, Nicola Tambasco, Anna Castagna, Daniela Cassano, Alfredo Berardelli

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia.MATERIALS AND METHODS: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia.RESULTS: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development.DISCUSSION AND CONCLUSION: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.
Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalParkinsonism and Related Disorders
Volume71
DOIs
Publication statusPublished - Jan 13 2020

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