Does brain infl ammation mediate pathological outcomes in epilepsy?

Karen S. Wilcox, Annamaria Vezzani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inflammation in the central nervous system (CNS) is associated with epilepsy and is characterized by the increased levels of a complex set of soluble molecules and their receptors in epileptogenic foci with profound neuromodulatory effects. These molecules activate receptor-mediated pathways in glia and neurons that contribute to hyperexcitability in neural networks that underlie seizure generation. As a consequence, exciting new opportunities now exist for novel therapies targeting the various components of the immune system and the associated infl ammatory mediators, especially the IL-1β system. This review summarizes recent fi ndings that increased our understanding of the role of infl ammation in reducing seizure threshold, contributing to seizure generation, and participating in epileptogenesis. We will discuss preclinical studies supporting the hypothesis that pharmacological inhibition of specifi c proinfl ammatory signalings may be useful to treat drug-resistant seizures in human epilepsy, and possibly delay or arrest epileptogenesis.

Original languageEnglish
Title of host publicationIssues in Clinical Epileptology: A View from the Bench
PublisherSpringer New York LLC
Pages169-183
Number of pages15
Volume813
ISBN (Print)9789401789134
DOIs
Publication statusPublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume813
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • IL-1β
  • IL-6
  • Infl ammation
  • Reactive astrogliosis
  • TNF-α

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Wilcox, K. S., & Vezzani, A. (2014). Does brain infl ammation mediate pathological outcomes in epilepsy? In Issues in Clinical Epileptology: A View from the Bench (Vol. 813, pp. 169-183). (Advances in Experimental Medicine and Biology; Vol. 813). Springer New York LLC. https://doi.org/10.1007/978-94-017-8914-1_14