Does brain inflammation mediate pathological outcomes in epilepsy?

Karen S. Wilcox, Annamaria Vezzani

Research output: Contribution to journalArticle

Abstract

Inflammation in the central nervous system (CNS) is associated with epilepsy and is characterized by the increased levels of a complex set of soluble molecules and their receptors in epileptogenic foci with profound neuromodulatory effects. These molecules activate receptor-mediated pathways in glia and neurons that contribute to hyperexcitability in neural networks that underlie seizure generation. As a consequence, exciting new opportunities now exist for novel therapies targeting the various components of the immune system and the associated inflammatory mediators, especially the IL-1β system. This review summarizes recent findings that increased our understanding of the role of inflammation in reducing seizure threshold, contributing to seizure generation, and participating in epileptogenesis. We will discuss preclinical studies supporting the hypothesis that pharmacological inhibition of specific proinflammatory signalings may be useful to treat drug-resistant seizures in human epilepsy, and possibly delay or arrest epileptogenesis.

Original languageEnglish
Pages (from-to)169-183
Number of pages15
JournalAdvances in Experimental Medicine and Biology
Volume813
DOIs
Publication statusPublished - 2014

    Fingerprint

Keywords

  • IL-1β
  • IL-6
  • Inflammation
  • Reactive astrogliosis
  • TNF-α

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this