Does Breastfeeding Protect Young Infants from Pertussis? Case-Control Study and Immunologic Evaluation

Elisabetta Pandolfi, Francesco Gesualdo, Emanuela Carloni, Alberto Villani, Fabio Midulla, Rita Carsetti, Paola Stefanelli, Giorgio Fedele, Alberto Eugenio Tozzi, for the Pertussis Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Pertussis infection can be severe in unvaccinated infants. A case control study was conducted to investigate the potential role of breastfeeding in protecting young, unvaccinated infants from pertussis. METHODS: Hospitalized infants < 6 months with positive RT-PCR for pertussis on nasopharyngeal aspirate were enrolled as cases; healthy controls were enrolled among patients admitted for ultrasound screening. Vaccinated infants were excluded. Sociodemographic, clinical and feeding information were collected. The effect of breastfeeding on pertussis was investigated through multivariable analysis. Breastmilk and blood samples were obtained from mothers of patients. IgA and bacterial binding against B. pertussis and other bacteria were tested in breastmilk. IgG against pertussis toxin (PT) was tested in serum. RESULTS: We enrolled 296 patients (61 cases, 235 controls). Exclusive breastfeeding was not associated with pertussis compared with partial breastfeeding/artificial feeding (OR 1.2; 95%CI 0.31–4.67). Children with siblings were at higher risk for pertussis (OR 2.5; 95%CI 1.21–5.35). IgA against pertussis antigens were not higher in cases (IgA anti-PT median=0.24 OD) compared with controls (IgA anti-PT median=0.21 OD). Though bacterial binding to B. pertussis, measured in breastmilk, was higher in cases (median=4.35%) compared to controls (median=2.8%, p=0.004), bacterial binding to B. pertussis was low compared with other pathogens. IgG titers were higher in mothers of cases, but no correlation was found between serum IgG and breastmilk IgA. CONCLUSION: Breastfeeding remains a mainstay of prevention for numerous diseases, though it does not seem to play a role against pertussis. Alternative strategies to protect unvaccinated infants from pertussis should be considered.

Original languageEnglish
JournalPediatric Infectious Disease Journal
DOIs
Publication statusAccepted/In press - Nov 18 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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