Does catheter ablation cure atrial fibrillation? Single-procedure outcome of drug-refractory atrial fibrillation ablation: A 6-year multicentre experience

Emanuele Bertaglia, Claudio Tondo, Antonio De Simone, Franco Zoppo, Massimo Mantica, Pietro Turco, Assunta Iuliano, Giovanni Forleo, Vincenzo La Rocca, Giuseppe Stabile

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Aims In the last decade, several approaches to ablating triggers and substrates of atrial fibrillation (AF) have been developed. However, most studies have reported data only on short- or medium-term follow-up. The aim of this study was to investigate whether the 1-year efficacy of catheter ablation for AF is predictive of long-term clinical success. Methods and results Between February 2001 and October 2003, 229 consecutive patients affected by drug-refractory paroxysmal or persistent AF underwent a single radiofrequency catheter ablation procedure (anatomical approach in 146 patients and electrophysiologically guided approach in 83 patients). Of these patients, 177 (mean age 59.1 ± 10.5 years, 57.6% with paroxysmal AF) were free from any atrial arrhythmia recurrence after 12 months. These 177 patients were subsequently followed up for at least another 24 months, by means of electrocardiogram and 24 h Holter monitoring. After a mean follow-up of 49.7 ± 13.3 months (range 36-83 months), 58.2% of the patients were free from any atrial arrhythmia recurrence (39.5% without antiarrhythmic drugs). The actuarial atrial arrhythmia recurrence rate was 13.0% at 2 years, 21.8% at 3 years, 35.0% at 4 years, 46.8% at 5 years, and 54.6% at 6 years. Atrial arrhythmia-free survival was similar in patients with paroxysmal or persistent AF, with and without antiarrhythmic drugs during the follow-up, who underwent electrophysiologically guided pulmonary vein (PV) isolation or anatomical PV ablation. Conclusion Even patients in whom catheter ablation prevents AF recurrence for 1 year should not be considered 'cured', since >40 of them will suffer AF recurrence over a long-term clinical follow-up.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalEuropace
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Catheter Ablation
Atrial Fibrillation
Pharmaceutical Preparations
Cardiac Arrhythmias
Recurrence
Pulmonary Veins
Anti-Arrhythmia Agents
Ambulatory Electrocardiography
Electrocardiography
Survival

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Long-term results

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Does catheter ablation cure atrial fibrillation? Single-procedure outcome of drug-refractory atrial fibrillation ablation : A 6-year multicentre experience. / Bertaglia, Emanuele; Tondo, Claudio; De Simone, Antonio; Zoppo, Franco; Mantica, Massimo; Turco, Pietro; Iuliano, Assunta; Forleo, Giovanni; La Rocca, Vincenzo; Stabile, Giuseppe.

In: Europace, Vol. 12, No. 2, 02.2010, p. 181-187.

Research output: Contribution to journalArticle

Bertaglia, E, Tondo, C, De Simone, A, Zoppo, F, Mantica, M, Turco, P, Iuliano, A, Forleo, G, La Rocca, V & Stabile, G 2010, 'Does catheter ablation cure atrial fibrillation? Single-procedure outcome of drug-refractory atrial fibrillation ablation: A 6-year multicentre experience', Europace, vol. 12, no. 2, pp. 181-187. https://doi.org/10.1093/europace/eup349
Bertaglia, Emanuele ; Tondo, Claudio ; De Simone, Antonio ; Zoppo, Franco ; Mantica, Massimo ; Turco, Pietro ; Iuliano, Assunta ; Forleo, Giovanni ; La Rocca, Vincenzo ; Stabile, Giuseppe. / Does catheter ablation cure atrial fibrillation? Single-procedure outcome of drug-refractory atrial fibrillation ablation : A 6-year multicentre experience. In: Europace. 2010 ; Vol. 12, No. 2. pp. 181-187.
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abstract = "Aims In the last decade, several approaches to ablating triggers and substrates of atrial fibrillation (AF) have been developed. However, most studies have reported data only on short- or medium-term follow-up. The aim of this study was to investigate whether the 1-year efficacy of catheter ablation for AF is predictive of long-term clinical success. Methods and results Between February 2001 and October 2003, 229 consecutive patients affected by drug-refractory paroxysmal or persistent AF underwent a single radiofrequency catheter ablation procedure (anatomical approach in 146 patients and electrophysiologically guided approach in 83 patients). Of these patients, 177 (mean age 59.1 ± 10.5 years, 57.6{\%} with paroxysmal AF) were free from any atrial arrhythmia recurrence after 12 months. These 177 patients were subsequently followed up for at least another 24 months, by means of electrocardiogram and 24 h Holter monitoring. After a mean follow-up of 49.7 ± 13.3 months (range 36-83 months), 58.2{\%} of the patients were free from any atrial arrhythmia recurrence (39.5{\%} without antiarrhythmic drugs). The actuarial atrial arrhythmia recurrence rate was 13.0{\%} at 2 years, 21.8{\%} at 3 years, 35.0{\%} at 4 years, 46.8{\%} at 5 years, and 54.6{\%} at 6 years. Atrial arrhythmia-free survival was similar in patients with paroxysmal or persistent AF, with and without antiarrhythmic drugs during the follow-up, who underwent electrophysiologically guided pulmonary vein (PV) isolation or anatomical PV ablation. Conclusion Even patients in whom catheter ablation prevents AF recurrence for 1 year should not be considered 'cured', since >40 of them will suffer AF recurrence over a long-term clinical follow-up.",
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AU - Zoppo, Franco

AU - Mantica, Massimo

AU - Turco, Pietro

AU - Iuliano, Assunta

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