Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group

Bernard Nordlinger, Eric Van Cutsem, Philippe Rougier, Claus Henning Köhne, Marc Ychou, Alberto Sobrero, Rene Adam, Dag Arvidsson, Alfredo Carrato, Vassilis Georgoulias, Felice Giuliante, Bengt Glimelius, Markus Golling, Thomas Gruenberger, Josep Tabernero, Harpreet Wasan, Graeme Poston

Research output: Contribution to journalArticlepeer-review

Abstract

Liver resection offers the only chance of cure for patients with advanced colorectal cancer (CRC). Typically, the 5-year survival rates following liver resection range from 25% to 40%. Unfortunately, approximately 85% of patients with stage IV CRC have liver disease which is considered unresectable at presentation. However, the rapid expansion in the use of improved combination therapy regimens has increased the percentage of patients eligible for potentially curative surgery. Despite this, the selection criteria for patients potentially suitable for resection are not well documented and patient management by multidisciplinary teams, although essential, is still evolving. The goal of the European Colorectal Metastases Treatment Group is to establish pan-European guidelines for the treatment of patients with CRC liver metastases that can be adopted more widely by established treatment centres and to develop more accurate staging systems and evaluation criteria.

Original languageEnglish
Pages (from-to)2037-2045
Number of pages9
JournalEuropean Journal of Cancer
Volume43
Issue number14
DOIs
Publication statusPublished - Sep 2007

Keywords

  • 5-Fluorouracil
  • Colorectal cancer
  • Irinotecan
  • Liver metastases
  • Liver resection
  • Neoadjuvant
  • Oxaliplatin
  • Perioperative chemotherapy
  • Targeted agents
  • Unresectable

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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