Does chronic raise of metal ion levels induce oxidative DNA damage and hypoxia-like response in patients with metal-on-metal hip resurfacing?

Lucia Savarino, Caterina Fotia, Laura Roncuzzi, Michelina Greco, Matteo Cadossi, Nicola Baldini, Sandro Giannini

Research output: Contribution to journalArticlepeer-review

Abstract

Metal-on-metal hip resurfacing (MOM-HR) represents a viable alternative to traditional arthroplasty. Nevertheless, in MOM coupling both metal nanoparticles and ions are released, whose toxicity remains a matter of concern. We investigated whether 'endogenous' chronic exposure to cobalt and chromium induced a state of oxidative stress, DNA damage and a hypoxia-like response in patients with well-functioning MOM-HR. Twenty-two patients with unilateral MOM-HR were recruited at long-term. Twenty-one osteoarthritic subjects were enrolled for comparison. Serum ion levels were measured and correlated with 8-hydroxydeoxyguanosine and circulating-free-DNA, as markers of oxidative DNA damage. Moreover, the hypoxia-inducible factor-1α, marker of hypoxic state, was evaluated. Ion concentrations were found to be 5-to-15 times higher in MOM-HR patients than in presurgery subjects (p

Original languageEnglish
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • Hip prosthesis
  • Metal ions
  • Metal-on-metal bearing
  • Toxicity
  • Wear

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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