Abstract
Metal-on-metal hip resurfacing (MOM-HR) represents a viable alternative to traditional arthroplasty. Nevertheless, in MOM coupling both metal nanoparticles and ions are released, whose toxicity remains a matter of concern. We investigated whether 'endogenous' chronic exposure to cobalt and chromium induced a state of oxidative stress, DNA damage and a hypoxia-like response in patients with well-functioning MOM-HR. Twenty-two patients with unilateral MOM-HR were recruited at long-term. Twenty-one osteoarthritic subjects were enrolled for comparison. Serum ion levels were measured and correlated with 8-hydroxydeoxyguanosine and circulating-free-DNA, as markers of oxidative DNA damage. Moreover, the hypoxia-inducible factor-1α, marker of hypoxic state, was evaluated. Ion concentrations were found to be 5-to-15 times higher in MOM-HR patients than in presurgery subjects (p
Original language | English |
---|---|
Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
DOIs | |
Publication status | Accepted/In press - 2015 |
Keywords
- Hip prosthesis
- Metal ions
- Metal-on-metal bearing
- Toxicity
- Wear
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials