Does clonidine added to epidural infusion of u.2w/o ropivacaine enhance postoperative analgesia in adults ?

Negri De Pasquale, Visconti Giro, Vivo De Paolo, Borrelli Felice, Giorgio Ivani, Puopolo Maria, Chiarotti Flavia

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INTRODUCTION Postoperative pain control is the big challenge to face in patients; results from previous studies suggested that the quality of postoperative epidural analgesia reflects on outcome. Ropivacaine showed less central nervous system and cardiac toxicity and produced less motor blockade if compared to bupivacaine; due to these characteristics 0.2% ropivacaine may be better suitable to epidural infusions for postoperative pain treatment In order to reduce the incidence of side effects, local anesthetic is usually combined with additives such as opioid or alpha 2 adrenergic agonist like clonidine; the utility of postoperative epidural clonidine is limited by hemodynamic modifications and sedation (supraspinal effects) due to systemic absorption. While epidural ropivacaine has been evaluated in combination with an opioid, no data are reported about the combination of ropivacaine with clonidine for postoperative analgesia in adult patients. Aim of this randomized, double-blind study was to determine if clonidine associated to epidural ropivacaine improves postoperative analgesia and the clonidine adequate dose rate that would reduce at minimum its effects on hemodynamic state and sedation. METHODS: After obtaining IRB approval and written informed consent from each patient, we studied in our prospective, randomized, double blind study 40 patients, ASA I-III, aged 25-69 scheduled for urologie surgery (kidney and ureter). No patients received preanesthetic medication. All patients received epidural catheterization (Sevit

Original languageEnglish
Pages (from-to)39
Number of pages1
JournalRegional Anesthesia and Pain Medicine
Issue number2 SUPPL.
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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