TY - JOUR
T1 - Does cytogenetic evolution have any prognostic relevance in myelodysplastic syndromes? A study on 153 patients from a single institution
AU - Bernasconi, Paolo
AU - Klersy, Catherine
AU - Boni, Marina
AU - Cavigliano, Paola Maria
AU - Giardini, Ilaria
AU - Rocca, Barbara
AU - Zappatore, Rita
AU - Dambruoso, Irene
AU - Calvello, Celeste
AU - Caresana, Marilena
AU - Lazzarino, Mario
PY - 2010/6
Y1 - 2010/6
N2 - The present study was designed to establish the incidence of cytogenetic evolution (CE), defined as the acquisition of chromosomal defects during the course of MDS, in order to correlate it with the WHO classification and IPSS score, and to assess its impact on overall survival (OS) and risk of MDS/AML evolution (progression-free interval, PFI) by means of Cox models for time-dependent covariates. Adjustments for known risk factors were achieved by performing a bivariable analysis. The study was carried out in 153 MDS patients who were followed for a median period of 45.2 months. Disease progression occurred in 42.4% of patients after a 65.2-month median PFI, while CE occurred in 30.7% of patients. Our study shows that (1) CE was more common in advanced than in early MDS, and advanced MDS presented secondary chromosomal defects distinct from those of early MDS; (2) CE significantly affected OS and PFI independently of other prognostic variables; (3) del(7)(q31q34) was the only secondary chromosomal defect which significantly affected PFI; trisomy 8 had only a moderate influence.
AB - The present study was designed to establish the incidence of cytogenetic evolution (CE), defined as the acquisition of chromosomal defects during the course of MDS, in order to correlate it with the WHO classification and IPSS score, and to assess its impact on overall survival (OS) and risk of MDS/AML evolution (progression-free interval, PFI) by means of Cox models for time-dependent covariates. Adjustments for known risk factors were achieved by performing a bivariable analysis. The study was carried out in 153 MDS patients who were followed for a median period of 45.2 months. Disease progression occurred in 42.4% of patients after a 65.2-month median PFI, while CE occurred in 30.7% of patients. Our study shows that (1) CE was more common in advanced than in early MDS, and advanced MDS presented secondary chromosomal defects distinct from those of early MDS; (2) CE significantly affected OS and PFI independently of other prognostic variables; (3) del(7)(q31q34) was the only secondary chromosomal defect which significantly affected PFI; trisomy 8 had only a moderate influence.
KW - Cytogenetics
KW - Myelodysplastic syndromes
KW - Prognostic factors
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U2 - 10.1007/s00277-010-0927-z
DO - 10.1007/s00277-010-0927-z
M3 - Article
C2 - 20217086
AN - SCOPUS:77951644972
VL - 89
SP - 545
EP - 551
JO - Revue d'hématologie
JF - Revue d'hématologie
SN - 0939-5555
IS - 6
ER -