Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy

F. Abdollah, A. Briganti, N. Suardi, A. Gallina, U. Capitanio, A. Salonia, A. Cestari, G. Guazzoni, P. Rigatti, F. Montorsi

Research output: Contribution to journalArticlepeer-review

Abstract

The objective was to test the hypothesis that in patients with prostate cancer undergoing radical prostatectomy (RP), diabetic patients are at a higher risk of harboring a high-grade tumor than non-diabetic patients. We examined 2060 consecutive men who underwent RP between 2001 and 2009. Of them, 7.1% had type 2 diabetes mellitus (DM). A high-grade tumor was defined as having a Gleason score ≥8. Univariable and multivariable logistic regression analyses were used to test the relationship between type 2 DM and high-grade tumor. Mean patient age was 64 years (range: 45-85). Mean total PSA level was 9 ng ml 1 (range: 1-89.5). A significantly higher percentage of diabetic patients had high-grade tumor on biopsy (16.3 vs 7.6%; P=0.001) and on RP specimen (21.1 vs 11.7%; P=0.001) in comparison with non-diabetic patients. In multivariable analyses, DM was an independent predictor of high-grade tumor on biopsy (odds ratio2.31, P=0.001) and on final pathological specimen (odds ratio=2.22, P=0.002). In patients undergoing RP, those with type 2 DM had a higher risk of harboring a poorly differentiated tumor on final pathological examination.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalProstate Cancer and Prostatic Diseases
Volume14
Issue number1
DOIs
Publication statusPublished - Mar 2011

Keywords

  • diabetes mellitus
  • Gleason score
  • tumor grade

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

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