Does Down's syndrome support the homocysteine theory of atherogenesis?. Experience in elderly subjects with trisomy 21

Federico Licastro, Alessandro Marocchi, Silvana Penco, Elisa Porcellini, Domenico Lio, Giada Dogliotti, Massimiliano M. Corsi

Research output: Contribution to journalArticlepeer-review

Abstract

Down syndrome (DS) is generally considered as an "atheroma-free model". In this preliminary study, we investigated homocysteine, folate and Vitamin B12 levels in 13 DS patients (male, average age 60 years) and 20 age-matched individuals. We also studied lipid fractions, and polymorphisms for Cystothionine β-synthase (CBS), 5,10-methyl-tetrahydro-folate reductase (MTHFR) and apolipoprotein E (Apo-E) genes. However, DS patients with the MTHFR TT genotype showed an increased of plasma homocysteine (tHcy). Our results indicate that this group of "healthy old" Down syndrome patients, although showing some classical biochemical risk factors for atherosclerosis, did not suffer clinical cardiovascular alterations.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume43
Issue number3
DOIs
Publication statusPublished - Nov 2006

Keywords

  • 5,10-Methyl-tetrahydro-folate reductase (MTHFR)
  • Apo ε4
  • Apo-A
  • Apo-B
  • Cystothionine β-synthase (CBS)
  • Down syndrome
  • Folate
  • Homocysteine
  • Vitamin B

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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