Does fatigue in Parkinson’s disease correlate with autonomic nervous system dysfunction?

Enrica Olivola, Livia Brusa, Camilla Rocchi, Orazio Schillaci, Claudio Liguori, Rocco Cerroni, Mariangela Pierantozzi, Agostino Chiaravalloti, Alessandro Stefani, Fabrizio Stocchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Despite its negative impact on quality of life, fatigue in Parkinson’s disease (PD) remains an under-recognized issue and the underlying pathology is undetermined. Objective: To contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD patients. Methods: In a Caucasian population of PD patients (n = 27), we evaluated to what extent fatigue (quantified as PFS-16 score) is associated with PD duration and with autonomic dysfunction, studied by both MIBG scintigraphy and autonomic nervous system testing. The latter included the head-up tilt test, Valsalva maneuver, deep breathing, and handgrip tests. Results: PFS-16 score correlated with disease duration (R = 0.57, p = 0.002). Fatigue showed a clear correlation with deep breathing test (R = − 0.53, p = 0.004) but not with the MIBG H/M ratios. Conclusions: Our data are consistent with a multifactorial pathogenesis of fatigue and with effects of dopamine depletion in PD-related fatigue; on the other hand, our findings do not support a role for sympathetic denervation in PD-related fatigue.

Original languageEnglish
Pages (from-to)2169-2174
Number of pages6
JournalNeurological Sciences
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 1 2018

Fingerprint

Autonomic Nervous System
Fatigue
Parkinson Disease
3-Iodobenzylguanidine
Respiration
Valsalva Maneuver
Sympathectomy
Radionuclide Imaging
Dopamine
Head
Quality of Life
Pathology
Population

Keywords

  • Autonomic nervous system
  • Fatigue
  • Myocardial scintigraphy
  • Parkinson’s disease

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Does fatigue in Parkinson’s disease correlate with autonomic nervous system dysfunction? / Olivola, Enrica; Brusa, Livia; Rocchi, Camilla; Schillaci, Orazio; Liguori, Claudio; Cerroni, Rocco; Pierantozzi, Mariangela; Chiaravalloti, Agostino; Stefani, Alessandro; Stocchi, Fabrizio.

In: Neurological Sciences, Vol. 39, No. 12, 01.12.2018, p. 2169-2174.

Research output: Contribution to journalArticle

Olivola, E, Brusa, L, Rocchi, C, Schillaci, O, Liguori, C, Cerroni, R, Pierantozzi, M, Chiaravalloti, A, Stefani, A & Stocchi, F 2018, 'Does fatigue in Parkinson’s disease correlate with autonomic nervous system dysfunction?', Neurological Sciences, vol. 39, no. 12, pp. 2169-2174. https://doi.org/10.1007/s10072-018-3569-x
Olivola E, Brusa L, Rocchi C, Schillaci O, Liguori C, Cerroni R et al. Does fatigue in Parkinson’s disease correlate with autonomic nervous system dysfunction? Neurological Sciences. 2018 Dec 1;39(12):2169-2174. https://doi.org/10.1007/s10072-018-3569-x
Olivola, Enrica ; Brusa, Livia ; Rocchi, Camilla ; Schillaci, Orazio ; Liguori, Claudio ; Cerroni, Rocco ; Pierantozzi, Mariangela ; Chiaravalloti, Agostino ; Stefani, Alessandro ; Stocchi, Fabrizio. / Does fatigue in Parkinson’s disease correlate with autonomic nervous system dysfunction?. In: Neurological Sciences. 2018 ; Vol. 39, No. 12. pp. 2169-2174.
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