TY - JOUR
T1 - Does fatigue in Parkinson’s disease correlate with autonomic nervous system dysfunction?
AU - Olivola, Enrica
AU - Brusa, Livia
AU - Rocchi, Camilla
AU - Schillaci, Orazio
AU - Liguori, Claudio
AU - Cerroni, Rocco
AU - Pierantozzi, Mariangela
AU - Chiaravalloti, Agostino
AU - Stefani, Alessandro
AU - Stocchi, Fabrizio
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Background: Despite its negative impact on quality of life, fatigue in Parkinson’s disease (PD) remains an under-recognized issue and the underlying pathology is undetermined. Objective: To contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD patients. Methods: In a Caucasian population of PD patients (n = 27), we evaluated to what extent fatigue (quantified as PFS-16 score) is associated with PD duration and with autonomic dysfunction, studied by both MIBG scintigraphy and autonomic nervous system testing. The latter included the head-up tilt test, Valsalva maneuver, deep breathing, and handgrip tests. Results: PFS-16 score correlated with disease duration (R = 0.57, p = 0.002). Fatigue showed a clear correlation with deep breathing test (R = − 0.53, p = 0.004) but not with the MIBG H/M ratios. Conclusions: Our data are consistent with a multifactorial pathogenesis of fatigue and with effects of dopamine depletion in PD-related fatigue; on the other hand, our findings do not support a role for sympathetic denervation in PD-related fatigue.
AB - Background: Despite its negative impact on quality of life, fatigue in Parkinson’s disease (PD) remains an under-recognized issue and the underlying pathology is undetermined. Objective: To contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD patients. Methods: In a Caucasian population of PD patients (n = 27), we evaluated to what extent fatigue (quantified as PFS-16 score) is associated with PD duration and with autonomic dysfunction, studied by both MIBG scintigraphy and autonomic nervous system testing. The latter included the head-up tilt test, Valsalva maneuver, deep breathing, and handgrip tests. Results: PFS-16 score correlated with disease duration (R = 0.57, p = 0.002). Fatigue showed a clear correlation with deep breathing test (R = − 0.53, p = 0.004) but not with the MIBG H/M ratios. Conclusions: Our data are consistent with a multifactorial pathogenesis of fatigue and with effects of dopamine depletion in PD-related fatigue; on the other hand, our findings do not support a role for sympathetic denervation in PD-related fatigue.
KW - Autonomic nervous system
KW - Fatigue
KW - Myocardial scintigraphy
KW - Parkinson’s disease
U2 - 10.1007/s10072-018-3569-x
DO - 10.1007/s10072-018-3569-x
M3 - Article
VL - 39
SP - 2169
EP - 2174
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 12
ER -