Does gabexate mesilate affect serum concentrations of acute phase proteins after endoscopic retrograde cholangiopancreatography examination?

Raffaele Pezzilli, Armando Gabbrielli, Antonio Maria Morselli Labate, Pasquale D'Alessio, Bahjat Barakat, Guido Costamagna, Francesco Dibenedetti, Margherita Massa, Giovanni Merlini, Gianvico Melzi D'Eril

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: To explore the possibility that the preventive effect of gabexate mesilate on endoscopic retrograde cholangiopancreatography-related acute pancreatitis may be mediated by its modulation of acute phase proteins. Methodology: Thirty consecutive patients who underwent endoscopic retrograde cholangiopancreatography were randomly assigned to receive 1g of gabexate mesilate (13 patients) or a placebo (17 patients) by continuous i.v. infusion starting 30 minutes before the endoscopy session and continuing for 12 hours afterward. In all patients, C-reactive protein, serum amyloid A and interleukin 6 serum concentrations were determined before endoscopy and 4, 8, 12 and 24 hours afterward. Results: Interleukin 6 basal serum concentrations were not statistically different between patients who had been treated with gabexate mesilate and those who had received the placebo (P=0.279), whereas C-reactive protein (P=0.033) and serum amyloid A (P=0.022) basal values were significantly lower in the gabexate mesilate group than in the placebo group. Compared to basal values, serum interleukin 6 concentrations significantly increased at 4 (P=0.048) and at 8 (P=0.025) hours; the increase of serum interleukin 6 concentrations was not significant at 12 (P=0.092), but became significant at 24 (P=0.025) hours. C-reactive protein and serum amyloid A serum concentrations increased significantly only at 12 (P=0.001, P=0.012, respectively) and 24 (P

Original languageEnglish
Pages (from-to)851-855
Number of pages5
JournalHepato-Gastroenterology
Volume50
Issue number51
Publication statusPublished - May 2003

Keywords

  • Acute Phase Proteins
  • Clinical Study
  • ERCP
  • Gabexate
  • Pancreatitis

ASJC Scopus subject areas

  • Gastroenterology

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