TY - JOUR
T1 - Does graves' disease during puberty influence adult bone mineral density?
AU - Radetti, Giorgio
AU - Bona, G.
AU - Corrias, A.
AU - Cappa, M.
AU - DeSanctis, V.
AU - Lauriola, S.
AU - Paganini, C.
AU - Rigon, F.
PY - 2002
Y1 - 2002
N2 - Aim: To evaluate the bone mineral density at lumbar spine and at femoral neck in a group of young adults in whom Graves' disease developed during childhood and adolescence. Patients and Methods: We examined 28 patients (5 male, 23 female, age 20.9 ± 3.3 years) who were 11.8 ± 2.9 years old at the onset of Graves' disease. They were treated either with methimazole (14 patients) or with methimazole plus l-thyroxine (14 patients). At the time of the investigation, 13 patients were considered cured following antithyroid treatment, 2 were still on antithyroid drugs, 3 were on replacement therapy with l-thyroxine because of hypothyroidism, and 10, treated either surgically or with 131I, were on replacement therapy. The bone mineral density was measured at the lumbar spine (L2-L4) and at the femoral neck, using dual-energy X-ray absorptiometry. Results: The spinal bone mineral density SD score was -0.28 ± 1.02, the femoral neck bone mineral density SD score was 0.36 ± 1.02, and both were not different from zero (NS). We did not find any correlation between the bone mineral density of the femoral neck and that of the lumbar spine and the clinical parameters. Conclusion: Graves' disease, beginning in childhood and adolescence, when appropriately treated, does not affect attainment of peak bone mass.
AB - Aim: To evaluate the bone mineral density at lumbar spine and at femoral neck in a group of young adults in whom Graves' disease developed during childhood and adolescence. Patients and Methods: We examined 28 patients (5 male, 23 female, age 20.9 ± 3.3 years) who were 11.8 ± 2.9 years old at the onset of Graves' disease. They were treated either with methimazole (14 patients) or with methimazole plus l-thyroxine (14 patients). At the time of the investigation, 13 patients were considered cured following antithyroid treatment, 2 were still on antithyroid drugs, 3 were on replacement therapy with l-thyroxine because of hypothyroidism, and 10, treated either surgically or with 131I, were on replacement therapy. The bone mineral density was measured at the lumbar spine (L2-L4) and at the femoral neck, using dual-energy X-ray absorptiometry. Results: The spinal bone mineral density SD score was -0.28 ± 1.02, the femoral neck bone mineral density SD score was 0.36 ± 1.02, and both were not different from zero (NS). We did not find any correlation between the bone mineral density of the femoral neck and that of the lumbar spine and the clinical parameters. Conclusion: Graves' disease, beginning in childhood and adolescence, when appropriately treated, does not affect attainment of peak bone mass.
KW - Antithyroid treatment
KW - Bone mineral density
KW - Dual-energy X-ray absorptiometry
KW - Graves' disease
UR - http://www.scopus.com/inward/record.url?scp=0036386952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036386952&partnerID=8YFLogxK
U2 - 10.1159/000065491
DO - 10.1159/000065491
M3 - Article
C2 - 12324715
AN - SCOPUS:0036386952
VL - 58
SP - 176
EP - 179
JO - Hormone Research
JF - Hormone Research
SN - 0301-0163
IS - 4
ER -