Does headache represent a clinical marker in early diagnosis of cerebral venous thrombosis? A prospective multicentric study

S. Iurlaro, E. Beghi, N. Massetto, A. Guccione, M. Autunno, B. Colombo, T. Di Monda, M. Gionco, P. Cortelli, F. Perini, F. D'Onofrio, E. Agostoni

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Abstract

The main aim of this study is to look for early clinical markers of cerebral venous thrombosis (CVT). As headache represents the major clinical manifestation at presentation we focused our attention on this symptom. We present the preliminary results of a prospective multicentric study that includes cases diagnosed as CVT in the participating centres. We have so far studied 35 patients (5 males and 30 females) from the ages of 18 to 78. The most frequent manifestation was headache (77.1%). It was more frequently localised (66.7%) and continuous (77.8%). The onset of pain was mostly acute-subacute (38.5%-50.0%) and the intensity moderate-severe (37.0%-51.9%). On univariate analysis, we found a positive correlation between CVT, acute headache onset (p=0.001) and severe headache (p=0.004). These preliminary results seem in accordance with our previous findings in the retrospective study, suggesting that CVT is more often associated with acute-onset headache of severe intensity.

Original languageEnglish
JournalNeurological Sciences
Volume25
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Oct 2004

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Intracranial Thrombosis
Venous Thrombosis
Headache
Early Diagnosis
Biomarkers
Prospective Studies
Retrospective Studies
Pain

Keywords

  • Cerebral venous thrombosis
  • Early diagnosis
  • Headache

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Does headache represent a clinical marker in early diagnosis of cerebral venous thrombosis? A prospective multicentric study. / Iurlaro, S.; Beghi, E.; Massetto, N.; Guccione, A.; Autunno, M.; Colombo, B.; Di Monda, T.; Gionco, M.; Cortelli, P.; Perini, F.; D'Onofrio, F.; Agostoni, E.

In: Neurological Sciences, Vol. 25, No. SUPPL. 3, 10.2004.

Research output: Contribution to journalArticle

Iurlaro, S. ; Beghi, E. ; Massetto, N. ; Guccione, A. ; Autunno, M. ; Colombo, B. ; Di Monda, T. ; Gionco, M. ; Cortelli, P. ; Perini, F. ; D'Onofrio, F. ; Agostoni, E. / Does headache represent a clinical marker in early diagnosis of cerebral venous thrombosis? A prospective multicentric study. In: Neurological Sciences. 2004 ; Vol. 25, No. SUPPL. 3.
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