Does HLA class II haplotype play a role in adult acute disseminated encephalomyelitis? Preliminary findings from a southern italy hospital-based study

D. Imbesi, R. S. Calabrò, G. Gervasi, C. Casella, G. Vita, R. Musolino

Research output: Contribution to journalArticle

Abstract

Acute Disseminated Encephalomyelitis (ADEM) is an acute, multifocal, monophasic, inflammatory demyelinating disease of the central nervous system that affects predominantly children. Aim of the study was to evaluate the distribution of Human Leukocyte Antigen (HLA) class II haplotype in adult ADEM patients, in order to better characterize this rare clinical entity. Six patients (3 males and 3 females; median age 50 years) with ADEM were retrospectively studied in our Neurology Unit; 29 healthy subjects (8 males and 21 females, mean age 43.4 ± 14.3) were the control group. All the study subjects were molecularly typed for HLA class II haplotype. The frequencies of HLA-DRB1*16 (17% vs. 3% in control group; Py = 0.02) and HLA-DQB1*05 (42% against 24% in the control group; Py = 0.010), as well as the association HLA-DRB1*16/HLA-DQB1*05 were significantly increased in ADEM population compared to the control group. The frequencies of allelic association between 13-04 (p <0.01) and homozygosis 14 (p <0.05) alleles at HLA-DRB1* locus and 05-02 (p > 0.05) alleles at HLA-DQB1* locus also were increased in ADEM patients. Our preliminary data provide further evidence that the HLA-DR/DQ haplotypes may be involved in susceptibility to immunomediate demyelinating diseases of central nervous system in the Caucasian population.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalArchives Italiennes de Biologie
Volume150
Issue number1
Publication statusPublished - 2012

Fingerprint

Acute Disseminated Encephalomyelitis
HLA Antigens
Haplotypes
Italy
Control Groups
Demyelinating Diseases
Central Nervous System
Neurology
Population
Healthy Volunteers
Alleles

Keywords

  • ADEM
  • Haplotypes
  • HLA-DR/DQ
  • Immunomediate demyelinating disease

ASJC Scopus subject areas

  • Medicine(all)
  • Cell Biology
  • Physiology

Cite this

Does HLA class II haplotype play a role in adult acute disseminated encephalomyelitis? Preliminary findings from a southern italy hospital-based study. / Imbesi, D.; Calabrò, R. S.; Gervasi, G.; Casella, C.; Vita, G.; Musolino, R.

In: Archives Italiennes de Biologie, Vol. 150, No. 1, 2012, p. 1-4.

Research output: Contribution to journalArticle

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