Does hyperprolactinemia affect hepatic regeneration independent of sex steroids?

D. Kahn, J. S. Gavaler, L. Makowka, P. Chapchap, V. Mazzaferro, A. Casavilla, M. S. Smith, P. K. Eagon, T. E. Starzl, D. H. Van Thiel

Research output: Contribution to journalArticle

Abstract

Prolactin, administered exogeneously, has been shown to be trophic to the liver, causing increases in the liver weight-to-body weight ratio, in ornithine decarboxylase activity, and in thymidine kinase activity. To investigate the effect of endogenous hyperprolactinemia on hepatic regeneration, pituitary isografts were placed beneath the renal capsule in rats 2 weeks before the rats underwent a two-thirds partial hepatectomy. Prolactin levels 2 weeks after the transplant were greater in the animals with the pituitary isografts compared with levels in controls. The increase in the liver weight-to-body weight ratio after hepatectomy was similar in the rats with pituitary transplant and the controls. However, chronic hyperprolactinemia was associated with increased basal levels of ornithine decarboxylase activity and thymidine kinase activity. Both ornithine decarboxylase activity and thymidine kinase activity increased after partial hepatectomy, and the magnitude of the changes was similar for both groups of animals. The levels of estrogen receptor activity before the partial hepatectomy and the reduction in receptor activity that follows partial hepatectomy were similar in the two groups of animals. Moreover, the levels of androgen receptor activity within the liver before partial hepatectomy and the increase in receptor activity after hepatectomy were similar in the two groups of animals. Thus, chronic sustained hyperprolactinemia has no beneficial effect on the hepatic regenerative response, despite induction of both basal ornithine decarboxylase and thymidine kinase activities.

Original languageEnglish
Pages (from-to)644-651
Number of pages8
JournalThe Journal of Laboratory and Clinical Medicine
Volume112
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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    Kahn, D., Gavaler, J. S., Makowka, L., Chapchap, P., Mazzaferro, V., Casavilla, A., Smith, M. S., Eagon, P. K., Starzl, T. E., & Van Thiel, D. H. (1988). Does hyperprolactinemia affect hepatic regeneration independent of sex steroids? The Journal of Laboratory and Clinical Medicine, 112(5), 644-651.