Does inhibition of Trypanosoma cruzi key enzymes affect parasite life cycle and geographic distribution?

Luca Salvati, Martino Bolognesi, Paolo Ascenzi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The hemoflagellate protozoan parasite Trypanosoma cruzi is the causative agent of the Chagas disease, a progressive fatal cardiomyopathy that afflicts more than 20 million people in Central and South America. The T. cruzi life cycle is affected by changes in temperature and pH, the parasite replication being facilitated in mammalian hosts rather than in insect vectors. Here, we postulate that the modulation of key enzymes by pH- and temperature-dependent substrate inhibition may affect the T. cruzi life cycle and limit the geographic range covered by the parasite.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalIUBMB Life
Volume53
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Trypanosoma cruzi
Life Cycle Stages
Life cycle
Parasites
Enzymes
Insect Vectors
Central America
Temperature
Chagas Disease
South America
Cardiomyopathies
Modulation
Substrates

Keywords

  • Enzyme modulation
  • Parasite geographic range
  • Parasite life cycle
  • Substrate inhibition
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Does inhibition of Trypanosoma cruzi key enzymes affect parasite life cycle and geographic distribution? / Salvati, Luca; Bolognesi, Martino; Ascenzi, Paolo.

In: IUBMB Life, Vol. 53, No. 1, 2002, p. 45-47.

Research output: Contribution to journalArticle

Salvati, Luca ; Bolognesi, Martino ; Ascenzi, Paolo. / Does inhibition of Trypanosoma cruzi key enzymes affect parasite life cycle and geographic distribution?. In: IUBMB Life. 2002 ; Vol. 53, No. 1. pp. 45-47.
@article{eec15f3e1f624d87b8681c01ead025f2,
title = "Does inhibition of Trypanosoma cruzi key enzymes affect parasite life cycle and geographic distribution?",
abstract = "The hemoflagellate protozoan parasite Trypanosoma cruzi is the causative agent of the Chagas disease, a progressive fatal cardiomyopathy that afflicts more than 20 million people in Central and South America. The T. cruzi life cycle is affected by changes in temperature and pH, the parasite replication being facilitated in mammalian hosts rather than in insect vectors. Here, we postulate that the modulation of key enzymes by pH- and temperature-dependent substrate inhibition may affect the T. cruzi life cycle and limit the geographic range covered by the parasite.",
keywords = "Enzyme modulation, Parasite geographic range, Parasite life cycle, Substrate inhibition, Trypanosoma cruzi",
author = "Luca Salvati and Martino Bolognesi and Paolo Ascenzi",
year = "2002",
doi = "10.1080/15216540210807",
language = "English",
volume = "53",
pages = "45--47",
journal = "IUBMB Life",
issn = "1521-6543",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Does inhibition of Trypanosoma cruzi key enzymes affect parasite life cycle and geographic distribution?

AU - Salvati, Luca

AU - Bolognesi, Martino

AU - Ascenzi, Paolo

PY - 2002

Y1 - 2002

N2 - The hemoflagellate protozoan parasite Trypanosoma cruzi is the causative agent of the Chagas disease, a progressive fatal cardiomyopathy that afflicts more than 20 million people in Central and South America. The T. cruzi life cycle is affected by changes in temperature and pH, the parasite replication being facilitated in mammalian hosts rather than in insect vectors. Here, we postulate that the modulation of key enzymes by pH- and temperature-dependent substrate inhibition may affect the T. cruzi life cycle and limit the geographic range covered by the parasite.

AB - The hemoflagellate protozoan parasite Trypanosoma cruzi is the causative agent of the Chagas disease, a progressive fatal cardiomyopathy that afflicts more than 20 million people in Central and South America. The T. cruzi life cycle is affected by changes in temperature and pH, the parasite replication being facilitated in mammalian hosts rather than in insect vectors. Here, we postulate that the modulation of key enzymes by pH- and temperature-dependent substrate inhibition may affect the T. cruzi life cycle and limit the geographic range covered by the parasite.

KW - Enzyme modulation

KW - Parasite geographic range

KW - Parasite life cycle

KW - Substrate inhibition

KW - Trypanosoma cruzi

UR - http://www.scopus.com/inward/record.url?scp=0036237277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036237277&partnerID=8YFLogxK

U2 - 10.1080/15216540210807

DO - 10.1080/15216540210807

M3 - Article

C2 - 12018407

AN - SCOPUS:0036237277

VL - 53

SP - 45

EP - 47

JO - IUBMB Life

JF - IUBMB Life

SN - 1521-6543

IS - 1

ER -