Does it look painful or disgusting? Ask your parietal and cingulate cortex

Francesca Benuzzi, Fausta Lui, Davide Duzzi, Paolo F. Nichelli, Carlo A. Porro

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Looking at still images of body parts in situations that are likely to cause pain has been shown to be associated with activation in some brain areas involved in pain processing. Because pain involves both sensory components and negative affect, it is of interest to explore whether the visually evoked representations of pain and of other negative emotions overlap. By means of event-related functional magnetic resonance imaging, here we compare the brain areas recruited, in female volunteers, by the observation of painful, disgusting, or neutral stimuli delivered to one hand or foot. Several cortical foci were activated by the observation of both painful and disgusting video clips, including portions of the medial prefrontal cortex, anterior, mid-, and posterior cingulate cortex, left posterior insula, and right parietal operculum. Signal changes in perigenual cingulate and left anterior insula were linearly related to the perceived unpleasantness, when the individual differences in susceptibility to aversive stimuli were taken into account. Painful scenes selectively induced activation of left parietal foci, including the parietal operculum, the postcentral gyrus, and adjacent portions of the posterior parietal cortex. In contrast, brain foci specific for disgusting scenes were found in the posterior cingulate cortex. These data show both similarities and differences between the brain patterns of activity related to the observation of noxious or disgusting stimuli. Namely, the parietal cortex appears to be particularly involved in the recognition of noxious environmental stimuli, suggesting that areas involved in sensory aspects of pain are specifically triggered by observing noxious events.

Original languageEnglish
Pages (from-to)923-931
Number of pages9
JournalJournal of Neuroscience
Volume28
Issue number4
DOIs
Publication statusPublished - Jan 23 2008

Fingerprint

Parietal Lobe
Gyrus Cinguli
Pain
Observation
Brain
Somatosensory Cortex
Prefrontal Cortex
Human Body
Surgical Instruments
Individuality
Foot
Volunteers
Emotions
Hand
Magnetic Resonance Imaging

Keywords

  • Cerebral cortex
  • Disgust
  • Empathy
  • Functional magnetic resonance imaging
  • Observation
  • Pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Does it look painful or disgusting? Ask your parietal and cingulate cortex. / Benuzzi, Francesca; Lui, Fausta; Duzzi, Davide; Nichelli, Paolo F.; Porro, Carlo A.

In: Journal of Neuroscience, Vol. 28, No. 4, 23.01.2008, p. 923-931.

Research output: Contribution to journalArticle

Benuzzi, F, Lui, F, Duzzi, D, Nichelli, PF & Porro, CA 2008, 'Does it look painful or disgusting? Ask your parietal and cingulate cortex', Journal of Neuroscience, vol. 28, no. 4, pp. 923-931. https://doi.org/10.1523/JNEUROSCI.4012-07.2008
Benuzzi, Francesca ; Lui, Fausta ; Duzzi, Davide ; Nichelli, Paolo F. ; Porro, Carlo A. / Does it look painful or disgusting? Ask your parietal and cingulate cortex. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 4. pp. 923-931.
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