Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases

Antonella Cuzzola, Edoardo Ferlazzo, Domenico Italiano, Rocco Salvatore Calabrò, Placido Bramanti, Pierre Genton

Research output: Contribution to journalArticle


Lennox-Gastaut syndrome is an intractable epileptic encephalopathy, with most patients experiencing daily seizures despite therapy with multiple antiepileptic drugs. New treatments need to be tested to define their efficacy in this syndrome. Lacosamide is a new antiepileptic drug recently approved for the treatment of partial-onset seizures. We describe three patients with Lennox-Gastaut syndrome resistant to conventional antiepileptic drugs whose seizures were aggravated by lacosamide.

Original languageEnglish
Pages (from-to)650-651
Number of pages2
JournalEpilepsy and Behavior
Issue number4
Publication statusPublished - Dec 2010



  • Lacosamide
  • Lennox-Gastaut syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this