Does malnutrition affect survival in cirrhosis?

Manuela Merli, Oliviero Riggio, Leonard Dally, Livio Capocaccia, Raffaella Lionetti, Massimo De Luca, Maria Anna Guardascione, Massimo Surrenti, Fabio Marra, Palo Gentilini, Gerardo Nardone, Gabriele Budillon, Carmela Loguercio, Camillo Del Vecchio Blanco, Mario Coltorti, Wilfredo Guglielmi, Antonio Francavilla, Giovanni Sandri, Mario Mazzetti Di Pietralata, Rossella LolliGiulio Marchesini, Angela Fava, Aido Spadaro, Pietro Paese, Angelo Belmonte, Maria Giovanna Graziani, Marino Luminari, Lorena Accorsi, Sergio Boccia, Franco Colella, Gabriella Tamaro, Gabriele Toigo, Giovanni Pedretti, Franco Fiaccadori, Riccardo Capocaccia

Research output: Contribution to journalArticlepeer-review

Abstract

A total of 1,053 cirrhotic patients were included in a prospective study to determine whether malnutrition is a risk factor for mortality in cirrhotic patients. ChildPugh classification as well as clinical and biochemical variables were used to assess the severity of cirrhosis. Nutritional status was evaluated both by anthropometric and clinical measurements. Patients were defined as malnourished when midarm muscle area (MAMA) and/or midarm fat area (MAFA) were below the 5th percentile of an age- and sex-matched population. During follow-up, 419 patients died. The estimated survival rate was 82.7% at 1 year, 65.1% at 3 years, and 50.7% at 5 years. The presence of muscle depletion and/or of a steep reduction in fat deposits was associated with a higher risk of mortality (midarm muscle area,

Original languageEnglish
Pages (from-to)1041-1046
Number of pages6
JournalHepatology
Volume23
Issue number5
DOIs
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Hepatology

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