Does palmitoylation target estrogen receptors to plasma membrane caveolae?

Filippo Acconcia, Alessio Bocedi, Paolo Ascenzi, Maria Marino

Research output: Contribution to journalArticle

Abstract

The human nuclear estrogen receptors (i.e., ERα and ERβ), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17β-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of transcriptional activity of the receptor and have been attributed to membrane ERs belonging to a signaling complex localized in caveolae. Here, we postulate that S-acylation of cysteine residue(s) present in the ligand binding domain of ERα and ERβ may play a critical role in the membrane caveolar localization of the receptor and in the formation of the 'steroid signalosome'.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalIUBMB Life
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Fingerprint

Lipoylation
Caveolae
Cell membranes
Estrogen Receptors
Cell Membrane
Membranes
Acylation
Cysteine
Estradiol
Steroids
Ligands

Keywords

  • 17β-estradiol
  • Caveolin
  • Estrogen receptor
  • Palmitoylation
  • Plasma membrane localization

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Does palmitoylation target estrogen receptors to plasma membrane caveolae? / Acconcia, Filippo; Bocedi, Alessio; Ascenzi, Paolo; Marino, Maria.

In: IUBMB Life, Vol. 55, No. 1, 01.01.2003, p. 33-35.

Research output: Contribution to journalArticle

Acconcia, F, Bocedi, A, Ascenzi, P & Marino, M 2003, 'Does palmitoylation target estrogen receptors to plasma membrane caveolae?', IUBMB Life, vol. 55, no. 1, pp. 33-35. https://doi.org/10.1080/1521654031000081256
Acconcia, Filippo ; Bocedi, Alessio ; Ascenzi, Paolo ; Marino, Maria. / Does palmitoylation target estrogen receptors to plasma membrane caveolae?. In: IUBMB Life. 2003 ; Vol. 55, No. 1. pp. 33-35.
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