Abstract
The human nuclear estrogen receptors (i.e., ERα and ERβ), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17β-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of transcriptional activity of the receptor and have been attributed to membrane ERs belonging to a signaling complex localized in caveolae. Here, we postulate that S-acylation of cysteine residue(s) present in the ligand binding domain of ERα and ERβ may play a critical role in the membrane caveolar localization of the receptor and in the formation of the 'steroid signalosome'.
Original language | English |
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Pages (from-to) | 33-35 |
Number of pages | 3 |
Journal | IUBMB Life |
Volume | 55 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1 2003 |
Keywords
- 17β-estradiol
- Caveolin
- Estrogen receptor
- Palmitoylation
- Plasma membrane localization
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology