Does palmitoylation target estrogen receptors to plasma membrane caveolae?

Filippo Acconcia, Alessio Bocedi, Paolo Ascenzi, Maria Marino

Research output: Contribution to journalArticlepeer-review

Abstract

The human nuclear estrogen receptors (i.e., ERα and ERβ), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17β-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of transcriptional activity of the receptor and have been attributed to membrane ERs belonging to a signaling complex localized in caveolae. Here, we postulate that S-acylation of cysteine residue(s) present in the ligand binding domain of ERα and ERβ may play a critical role in the membrane caveolar localization of the receptor and in the formation of the 'steroid signalosome'.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalIUBMB Life
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • 17β-estradiol
  • Caveolin
  • Estrogen receptor
  • Palmitoylation
  • Plasma membrane localization

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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